Capsaicin and Its analogues impede nocifensive response of caenorhabditis elegans to noxious heat
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Capsaicin is the most abundant pungent molecule identifed in red chili peppers, and it is widely used for food favoring,
in pepper spray for self-defense devices and recently in ointments for the relief of neuropathic pain. Capsaicin and several
other related vanilloid compounds are secondary plant metabolites. Capsaicin is a selective agonist of the transient receptor
potential channel, vanilloid subfamily member 1 (TRPV1). After exposition to vanilloid solution, Caenorhabditis elegans
wild type (N2) and mutants were placed on petri dishes divided in quadrants for heat stimulation. Thermal avoidance index
was used to phenotype each tested C. elegans experimental groups. The data revealed for the frst-time that capsaicin can
impede nocifensive response of C. elegans to noxious heat (32–35 °C) following a sustained exposition. The efect was
reversed 6 h post capsaicin exposition. Additionally, we identifed the capsaicin target, the C. elegans transient receptor
potential channel OCR-2 and not OSM-9. Further experiments also undoubtedly revealed anti-nociceptive efect for capsaicin
analogues, including olvanil, gingerol, shogaol and curcumin.
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