MRI-based R2* mapping in patients with suspected or known iron overload
dc.contributor.author | Aslan, Emre | |
dc.contributor.author | Luo, Jack W. | |
dc.contributor.author | Lesage, An | |
dc.contributor.author | Paquin, Philippe | |
dc.contributor.author | Cerny, Milena | |
dc.contributor.author | Chin, Anne Shu-Lei | |
dc.contributor.author | Olivié, Damien | |
dc.contributor.author | Gilbert, Guillaume | |
dc.contributor.author | Soulières, Denis | |
dc.contributor.author | Tang, An | |
dc.date.accessioned | 2023-06-19T18:53:17Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2023-06-19T18:53:17Z | |
dc.date.issued | 2021-01-02 | |
dc.identifier.uri | http://hdl.handle.net/1866/28265 | |
dc.publisher | Springer | fr |
dc.subject | Iron overload | fr |
dc.subject | Hemochromatosis | fr |
dc.subject | Transfusional hemosiderosis | fr |
dc.subject | MRI iron quantification | fr |
dc.subject | R2* | fr |
dc.title | MRI-based R2* mapping in patients with suspected or known iron overload | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Département de radiologie, radio-oncologie et médecine nucléaire | fr |
dc.identifier.doi | 10.1007/s00261-020-02912-w | |
dcterms.abstract | Purpose R2* relaxometry is a quantitative method for assessment of iron overload. The purpose is to analyze the cross-sectional relationships between R2* in organs across patients with primary and secondary iron overload. Secondary analyses were conducted to analyze R2* according to treatment regimen. Methods This is a retrospective, cross-sectional, institutional review board-approved study of eighty-one adult patients with known or suspected iron overload. R2* was measured by segmenting the liver, spleen, bone marrow, pancreas, renal cortex, renal medulla, and myocardium using breath-hold multi-echo gradient-recalled echo imaging at 1.5 T. Phlebotomy, transfusion, and chelation therapy were documented. Analyses included correlation, Kruskal–Wallis, and post hoc Dunn tests. p < 0.01 was considered significant. Results Correlations between liver R2* and that of the spleen, bone marrow, pancreas, and heart were respectively 0.49, 0.33, 0.27, and 0.34. R2* differed between patients with primary and secondary overload in the liver (p < 0.001), spleen (p < 0.001), bone marrow (p < 0.01), renal cortex (p < 0.001), and renal medulla (p < 0.001). Liver, spleen, and bone marrow R2* were higher in thalassemia than in hereditary hemochromatosis (all p < 0.01). Renal cortex R2* was higher in sickle cell disease than in hereditary hemochromatosis (p < 0.001) and in thalassemia (p < 0.001). Overall, there was a trend toward lower liver R2* in patients assigned to phlebotomy and higher liver R2* in patients assigned to transfusion and chelation therapy. Conclusion R2* relaxometry revealed differences in degree or distribution of iron overload between organs, underlying etiologies, and treatment. | fr |
dcterms.isPartOf | urn:ISSN:2366-004X | fr |
dcterms.isPartOf | urn:ISSN:2366-0058 | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | Aslan, E., Luo, J. W., Lesage, A., Paquin, P., Cerny, M., Chin, A. S., Olivié, D., Gilbert, G., Soulières, D., & Tang, A. (2021). MRI-based R2* mapping in patients with suspected or known iron overload. Abdominal radiology (New York), 46(6), 2505–2515. https://doi.org/10.1007/s00261-020-02912-w | fr |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | fr |
oaire.citationTitle | Abdominal radiology | fr |
oaire.citationVolume | 46 | fr |
oaire.citationIssue | 6 | fr |
oaire.citationStartPage | 2505 | fr |
oaire.citationEndPage | 2515 | fr |
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