dc.contributor.author | Hillhouse, Erin | |
dc.contributor.author | Delisle, Jean-Sébastien | |
dc.contributor.author | Lesage, Sylvie | |
dc.date.accessioned | 2023-01-30T14:16:59Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2023-01-30T14:16:59Z | |
dc.date.issued | 2013-01-13 | |
dc.identifier.uri | http://hdl.handle.net/1866/27369 | |
dc.publisher | Frontiers media | fr |
dc.rights | Ce document est mis à disposition selon les termes de la Licence Creative Commons
Paternité 3.0 non transposé / License Creative Commons Attribution 3.0 Unported | |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | |
dc.subject | Graft-vs-host disease | fr |
dc.subject | Autoimmunity | fr |
dc.subject | Cancer | fr |
dc.subject | Graft tolerance | fr |
dc.subject | Immunoregulation | fr |
dc.subject | Double negative T cells | fr |
dc.title | Immunoregulatory CD4-CD8- T cells as a potential therapeutic tool for transplantation, autoimmunity, and cancer | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Département de microbiologie, infectiologie et immunologie | fr |
dc.identifier.doi | 10.3389/fimmu.2013.00006 | |
dcterms.abstract | A central objective in organ transplantation and the treatment or prevention of autoimmune disease is the achievement of antigen-specific immune tolerance. An additional challenge in bone marrow transplantation for the treatment of hematological malignancies is the prevention of graft-vs-host disease (GVHD) while maintaining graft-vs-tumor activity. Interestingly, CD4-CD8- (double negative, DN) T cells, which exhibit a unique antigen-specific immunoregulatory potential, appear to exhibit all of the properties to respond to these challenges. Herein, we review the therapeutic potential of immunoregulatory DN T cells in various immunopathological settings, including graft tolerance, GVHD, cancer, and autoimmunity. | fr |
dcterms.isPartOf | urn:ISSN:1664-3224 | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | Front. Immunol., 24 January 2013
Sec. Immunological Tolerance and Regulation
Volume 4 - 2013 | https://doi.org/10.3389/fimmu.2013.00006 | fr |
UdeM.VersionRioxx | Version publiée / Version of Record | fr |
oaire.citationTitle | Frontiers in immunology | fr |
oaire.citationVolume | 4 | fr |