dc.contributor.author | Mohamed Moutuou, Moutuaata | |
dc.contributor.author | Pagé, Gabriel | |
dc.contributor.author | Zaid, Intesar | |
dc.contributor.author | Lesage, Sylvie | |
dc.contributor.author | Guimond, Martin | |
dc.date.accessioned | 2023-01-25T13:39:59Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2023-01-25T13:39:59Z | |
dc.date.issued | 2018-06-18 | |
dc.identifier.uri | http://hdl.handle.net/1866/27358 | |
dc.publisher | Frontiers Media | fr |
dc.rights | Ce document est mis à disposition selon les termes de la Licence Creative Commons
Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0
International License. | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/deed.fr | |
dc.subject | Interleukin-7 | fr |
dc.subject | Dendritic cells | fr |
dc.subject | Lymphopenia | fr |
dc.subject | Lymphocytes | fr |
dc.subject | Stem cell transplantation | fr |
dc.subject | GVHD | fr |
dc.subject | IL-7 | fr |
dc.subject | SDF-1α | fr |
dc.title | Restoring T cell homeostasis after allogeneic stem cell transplantation; principal limitations and future challenges | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Département de microbiologie, infectiologie et immunologie | fr |
dc.identifier.doi | 10.3389/fimmu.2018.01237 | |
dcterms.abstract | For several leukemia patients, allogeneic stem cell transplantation (allogeneic-SCT) is
the unique therapeutic modality that could potentially cure their disease. Despite significant progress made in clinical management of allogeneic-SCT, acute graft-versushost disease (aGVHD) and infectious complications remain the second and third cause
of death after disease recurrence. Clinical options to restore immunocompetence after
allogeneic-SCT are very limited as studies have raised awareness about the safety
with regards to graft-versus-host disease (GVHD). Preclinical works are now focusing
on strategies to improve thymic functions and to restore the peripheral niche that
have been damaged by alloreactive T cells. In this mini review, we will provide a brief
overview about the adverse effects of GVHD on the thymus and the peripheral niche
and the resulting negative outcome on peripheral T cell homeostasis. Finally, we will
discuss the potential relevance of coordinating our studies on thymic rejuvenation and
improvement of the peripheral lymphoid niche to achieve optimal T cell regeneration in
GVHD patients. | fr |
dcterms.isPartOf | urn:ISSN:1664-3224 | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | doi.org/10.3389/fimmu.2018.01237 | fr |
UdeM.VersionRioxx | Version publiée / Version of Record | fr |
oaire.citationTitle | Frontiers in immunology | fr |
oaire.citationVolume | 9 | fr |