dc.contributor.author | Chognard, Gaëlle | |
dc.contributor.author | Bellemare, Lisa | |
dc.contributor.author | Pelletier, Adam-Nicolas | |
dc.contributor.author | Domínguez Punaro, María de la Cruz | |
dc.contributor.author | Beauchamp, Claudine | |
dc.contributor.author | Guyon, Marie-Josée | |
dc.contributor.author | Charron, Guy | |
dc.contributor.author | Morin, Nicolas | |
dc.contributor.author | Sivanesan, Durga | |
dc.contributor.author | Kuchroo, Vijay | |
dc.contributor.author | Kuchroo, Vijay | |
dc.contributor.author | Michnick, Stephen | |
dc.contributor.author | Chemtob, Sylvain | |
dc.contributor.author | Rioux, John David | |
dc.contributor.author | Lesage, Sylvie | |
dc.date.accessioned | 2023-01-17T15:46:37Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2023-01-17T15:46:37Z | |
dc.date.issued | 2014-02-21 | |
dc.identifier.uri | http://hdl.handle.net/1866/27325 | |
dc.publisher | Public Library of Science | fr |
dc.rights | Ce document est mis à disposition selon les termes de la Licence Creative Commons
Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0
International License. | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | The dichotomous pattern of IL-12R and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Département de microbiologie, infectiologie et immunologie | fr |
dc.identifier.doi | 10.1371/journal.pone.0089092 | |
dcterms.abstract | IL-12 and IL-23 cytokines respectively drive Th1 and Th17 type responses. Yet, little is known regarding the biology of these receptors. As the IL-12 and IL-23 receptors share a common subunit, it has been assumed that these receptors are co-expressed. Surprisingly, we find that the expression of each of these receptors is restricted to specific cell types, in both mouse and human. Indeed, although IL-12Rβ2 is expressed by NK cells and a subset of γδ T cells, the expression of IL-23R is restricted to specific T cell subsets, a small number of B cells and innate lymphoid cells. By exploiting an IL-12- and IL-23-dependent mouse model of innate inflammation, we demonstrate an intricate interplay between IL-12Rβ2 NK cells and IL-23R innate lymphoid cells with respectively dominant roles in the regulation of systemic versus local inflammatory responses. Together, these findings support an unforeseen lineage-specific dichotomy in the in vivo role of both the IL-12 and IL-23 pathways in pathological inflammatory states, which may allow more accurate dissection of the roles of these receptors in chronic inflammatory diseases in humans. | fr |
dcterms.isPartOf | urn:ISSN:1932-6203 | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | https://doi.org/10.1371/journal.pone.0089092 | fr |
UdeM.VersionRioxx | Version publiée / Version of Record | fr |
oaire.citationTitle | PLoS one | fr |
oaire.citationVolume | 9 | fr |
oaire.citationIssue | 2 | fr |