dc.contributor.author | Dion, François | |
dc.contributor.author | Dumayne, Christopher | |
dc.contributor.author | Henley, Nathalie | |
dc.contributor.author | Beauchemin, Stéphanie | |
dc.contributor.author | Arias, Edward B. | |
dc.contributor.author | Leblond, François | |
dc.contributor.author | Lesage, Sylvie | |
dc.contributor.author | Lefrancois, Stephane | |
dc.contributor.author | Cartee, Gregory D. | |
dc.contributor.author | Pichette, Vincent | |
dc.date.accessioned | 2023-01-17T14:48:10Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2023-01-17T14:48:10Z | |
dc.date.issued | 2017-05-01 | |
dc.identifier.uri | http://hdl.handle.net/1866/27324 | |
dc.publisher | Public Library of Science | fr |
dc.rights | Ce document est mis à disposition selon les termes de la Licence Creative Commons
Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0
International License. | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Mechanism of insulin resistance in a rat model of kidney disease and the risk of developing type 2 diabetes | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Département de microbiologie, infectiologie et immunologie | fr |
dc.identifier.doi | 10.1371/journal.pone.0176650 | |
dcterms.abstract | Chronic kidney disease is associated with homeostatic imbalances such as insulin resistance. However, the underlying mechanisms leading to these imbalances and whether they
promote the development of type 2 diabetes is unknown. The effect of chronic kidney disease on insulin resistance was studied on two different rat strains. First, in a 5/6th nephrectomised Sprague-Dawley rat model of chronic kidney disease, we observed a correlation
between the severity of chronic kidney disease and hyperglycemia as evaluated by serum
fructosamine levels (p<0.0001). Further, glucose tolerance tests indicated an increase of
25% in glycemia in chronic kidney disease rats (p<0.0001) as compared to controls whereas
insulin levels remained unchanged. We also observed modulation of glucose transporters
expression in several tissues such as the liver (decrease of 40%, p 0.01) and muscles
(decrease of 29%, p 0.05). Despite a significant reduction of 37% in insulin-dependent
glucose uptake in the muscles of chronic kidney disease rats (p<0.0001), the development
of type 2 diabetes was never observed. Second, in a rat model of metabolic syndrome
(Zucker Leprfa/fa), chronic kidney disease caused a 50% increased fasting hyperglycemia
(p<0.0001) and an exacerbated glycemic response (p<0.0001) during glucose challenge.
Similar modulations of glucose transporters expression and glucose uptake were observed
in the two models. However, 30% (p<0.05) of chronic kidney disease Zucker rats developed
characteristics of type 2 diabetes. Thus, our results suggest that downregulation of GLUT4
in skeletal muscle may be associated with insulin resistance in chronic kidney disease and
could lead to type 2 diabetes in predisposed animals. | fr |
dcterms.isPartOf | urn:ISSN:1932-6203 | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | https://doi.org/10.1371/journal.pone.0176650 | fr |
UdeM.VersionRioxx | Version publiée / Version of Record | fr |
oaire.citationTitle | PLoS one | fr |
oaire.citationVolume | 12 | fr |
oaire.citationIssue | 5 | fr |