dc.contributor.author | Mola, Saraï | |
dc.contributor.author | Foisy, Sylvain | |
dc.contributor.author | Boucher, Gabrielle | |
dc.contributor.author | Major, François | |
dc.contributor.author | Beauchamp, Claudine | |
dc.contributor.author | Karaky, Mohamad | |
dc.contributor.author | Goyette, Philippe | |
dc.contributor.author | Lesage, Sylvie | |
dc.contributor.author | Rioux, John David | |
dc.date.accessioned | 2023-01-17T13:29:01Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2023-01-17T13:29:01Z | |
dc.date.issued | 2020-05-29 | |
dc.identifier.uri | http://hdl.handle.net/1866/27323 | |
dc.publisher | Public Library of Science | fr |
dc.rights | Ce document est mis à disposition selon les termes de la Licence Creative Commons
Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0
International License. | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | A transcriptome-based approach to identify functional modules within and across primary human immune cells | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Département de microbiologie, infectiologie et immunologie | fr |
dc.identifier.doi | 10.1371/journal.pone.0233543 | |
dcterms.abstract | Genome-wide transcriptomic analyses have provided valuable insight into fundamental biology and disease pathophysiology. Many studies have taken advantage of the correlation in
the expression patterns of the transcriptome to infer a potential biologic function of uncharacterized genes, and multiple groups have examined the relationship between co-expression,
co-regulation, and gene function on a broader scale. Given the unique characteristics of
immune cells circulating in the blood, we were interested in determining whether it was possible to identify functional co-expression modules in human immune cells. Specifically, we
sequenced the transcriptome of nine immune cell types from peripheral blood cells of healthy
donors and, using a combination of global and targeted analyses of genes within co-expression modules, we were able to determine functions for these modules that were cell lineagespecific or shared among multiple cell lineages. In addition, our analyses identified transcription factors likely important for immune cell lineage commitment and/or maintenance. | fr |
dcterms.isPartOf | urn:ISSN:1932-6203 | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | https://doi.org/10.1371/journal.pone.0233543 | fr |
UdeM.VersionRioxx | Version publiée / Version of Record | fr |
oaire.citationTitle | PLoS one | fr |
oaire.citationVolume | 15 | fr |
oaire.citationIssue | 5 | fr |