A longitudinal pilot study on cognition and cerebral hemodynamics in a mouse model of preeclampsia superimposed on hypertension : looking at mothers and their offspring
dc.contributor.author | Trigiani, Lianne J. | |
dc.contributor.author | Lecrux, Clotilde | |
dc.contributor.author | Royea, Jessika | |
dc.contributor.author | Lavoie, Julie | |
dc.contributor.author | Lesage, Frédéric | |
dc.contributor.author | Pilote, Louise | |
dc.contributor.author | Hamel, Edith | |
dc.date.accessioned | 2022-10-31T14:27:51Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2022-10-31T14:27:51Z | |
dc.date.issued | 2021-02-01 | |
dc.identifier.uri | http://hdl.handle.net/1866/26998 | |
dc.publisher | Frontiers Media | fr |
dc.subject | Preeclampsia | fr |
dc.subject | Cerebrovascular function | fr |
dc.subject | Cognition | fr |
dc.subject | Renin-angiotensin-aldosterone system | fr |
dc.subject | Cerebral hemodynamics | fr |
dc.title | A longitudinal pilot study on cognition and cerebral hemodynamics in a mouse model of preeclampsia superimposed on hypertension : looking at mothers and their offspring | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. École de kinésiologie et des sciences de l'activité physique | fr |
dc.identifier.doi | 10.3389/fphys.2021.611984 | |
dcterms.abstract | Preeclampsia is a common hypertensive disorder in pregnant women and whose causes and consequences have focused primarily on cardiovascular outcomes on the mother and offspring, often without taking into consideration the possible effects on the brain. One possible cause of preeclampsia has been attributed to alterations in the renin-angiotensin system, which has also been linked to cognitive decline. In this pilot study, we use a transgenic mouse model that chronically overexpresses human angiotensinogen and renin (R+A + mice) that displayed characteristics of preeclampsia such as proteinuria during gestation. Offspring of these mothers as well as from control mothers were also examined. We were primarily interested in detecting whether cognitive deficits were present in the mothers and offspring in the long term and used a spatial learning and memory task as well as an object recognition task at three timepoints: 3, 8, and 12 months post-partum or post-natal, while measuring blood pressure and performing urine analysis after each timepoint. While we did not find significant deficits in preeclamptic mothers at the later timepoints, we did observe negative consequences in the pups of R+A + mice that coincided with hemodynamic alterations whereby pups had higher whisker-evoked oxygenated hemoglobin levels and increased cerebral blood flow responses compared to control pups. Our study provides validation of this preeclampsia mouse model for future studies to decipher the underlying mechanisms of long-term cognitive deficits found in offspring. | fr |
dcterms.isPartOf | urn:ISSN:1664-042X | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | https://doi.org/10.3389/fphys.2021.611984 | fr |
UdeM.VersionRioxx | Version publiée / Version of Record | fr |
oaire.citationTitle | Frontiers in physiology | fr |
Files in this item
This item appears in the following Collection(s)
This document disseminated on Papyrus is the exclusive property of the copyright holders and is protected by the Copyright Act (R.S.C. 1985, c. C-42). It may be used for fair dealing and non-commercial purposes, for private study or research, criticism and review as provided by law. For any other use, written authorization from the copyright holders is required.