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dc.contributor.authorBen Ali Gannoun, Marwa
dc.contributor.authorRaguema, Nozha
dc.contributor.authorFoued, Zitouni
dc.contributor.authorMehdi, Meriem
dc.contributor.authorSeda, Ondrej
dc.contributor.authorMahjoub, Touhami
dc.contributor.authorLavoie, Julie
dc.date.accessioned2022-10-31T13:17:32Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2022-10-31T13:17:32Z
dc.date.issued2021-06-16
dc.identifier.urihttp://hdl.handle.net/1866/26996
dc.publisherMDPIfr
dc.rightsCe document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.fr
dc.subjectGenotypingfr
dc.subjectPreeclampsiafr
dc.subjectMMP-9fr
dc.subjectMMP-2fr
dc.subjectSNPsfr
dc.titleMMP-2 and MMP-9 polymorphisms and preeclampsia risk in tunisian arabs : a case-control studyfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté de médecine. École de kinésiologie et des sciences de l'activité physiquefr
dc.identifier.doi10.3390/jcm10122647
dcterms.abstractThe abnormal production of matrix metalloproteinases (MMPs), especially MMP-9 and MMP-2, plays a pivotal role in hypertensive disorders of pregnancy, and as such, can influence the development of preeclampsia. These alterations may result from functional genetic polymorphisms in the promoter region of MMP-9 and MMP-2 genes, which modify MMP-9 and MMP-2 expression. We investigated the association of MMP-9 polymorphism rs3918242 (-1562 C>T) and MMP-2 polymorphism rs2285053 (-735 C>T) with the risk of preeclampsia. This case–control study was conducted on 345 women with preeclampsia and 281 age-matched women with normal pregnancies from Tunisian hospitals. Genomic DNA was extracted from whole blood collected at delivery. Genotypes for -1562 C>T and -735 C>T polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). An increased frequency of heterozygous MMP-9 -1562 C/T genotype carriers was observed in women with preeclampsia compared to healthy controls (p = 0.03). In contrast, the MMP-2 -735 C>T polymorphism was not significantly different regarding frequency distribution of the allele and genotype between healthy pregnant women and women with preeclampsia. Our study suggests that the MMP-9 -1562 C/T variant, associated with high MMP-9 production, could be a genetic risk factor for preeclampsia in Tunisian women.fr
dcterms.isPartOfurn:ISSN:2077-0383fr
dcterms.languageengfr
UdeM.ReferenceFournieParDeposantdoi: 10.3390/jcm10122647fr
UdeM.VersionRioxxVersion publiée / Version of Recordfr
oaire.citationTitleJournal of clinical medicinefr
oaire.citationVolume10fr
oaire.citationIssue12fr


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Ce document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License.
Usage rights : Ce document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License.