dc.contributor.author | Ben Ali Gannoun, Marwa | |
dc.contributor.author | Raguema, Nozha | |
dc.contributor.author | Foued, Zitouni | |
dc.contributor.author | Mehdi, Meriem | |
dc.contributor.author | Seda, Ondrej | |
dc.contributor.author | Mahjoub, Touhami | |
dc.contributor.author | Lavoie, Julie | |
dc.date.accessioned | 2022-10-31T13:17:32Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2022-10-31T13:17:32Z | |
dc.date.issued | 2021-06-16 | |
dc.identifier.uri | http://hdl.handle.net/1866/26996 | |
dc.publisher | MDPI | fr |
dc.rights | Ce document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License. | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/deed.fr | |
dc.subject | Genotyping | fr |
dc.subject | Preeclampsia | fr |
dc.subject | MMP-9 | fr |
dc.subject | MMP-2 | fr |
dc.subject | SNPs | fr |
dc.title | MMP-2 and MMP-9 polymorphisms and preeclampsia risk in tunisian arabs : a case-control study | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. École de kinésiologie et des sciences de l'activité physique | fr |
dc.identifier.doi | 10.3390/jcm10122647 | |
dcterms.abstract | The abnormal production of matrix metalloproteinases (MMPs), especially MMP-9 and MMP-2, plays a pivotal role in hypertensive disorders of pregnancy, and as such, can influence the development of preeclampsia. These alterations may result from functional genetic polymorphisms in the promoter region of MMP-9 and MMP-2 genes, which modify MMP-9 and MMP-2 expression. We investigated the association of MMP-9 polymorphism rs3918242 (-1562 C>T) and MMP-2 polymorphism rs2285053 (-735 C>T) with the risk of preeclampsia. This case–control study was conducted on 345 women with preeclampsia and 281 age-matched women with normal pregnancies from Tunisian hospitals. Genomic DNA was extracted from whole blood collected at delivery. Genotypes for -1562 C>T and -735 C>T polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). An increased frequency of heterozygous MMP-9 -1562 C/T genotype carriers was observed in women with preeclampsia compared to healthy controls (p = 0.03). In contrast, the MMP-2 -735 C>T polymorphism was not significantly different regarding frequency distribution of the allele and genotype between healthy pregnant women and women with preeclampsia. Our study suggests that the MMP-9 -1562 C/T variant, associated with high MMP-9 production, could be a genetic risk factor for preeclampsia in Tunisian women. | fr |
dcterms.isPartOf | urn:ISSN:2077-0383 | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | doi: 10.3390/jcm10122647 | fr |
UdeM.VersionRioxx | Version publiée / Version of Record | fr |
oaire.citationTitle | Journal of clinical medicine | fr |
oaire.citationVolume | 10 | fr |
oaire.citationIssue | 12 | fr |