Metabotropic group II glutamate receptors in the basolateral amygdala mediate cue-triggered increases in incentive motivation
dc.contributor.author | Garceau, Caroline | |
dc.contributor.author | Samaha, Anne-Noël | |
dc.contributor.author | Cordahi, Thomas | |
dc.contributor.author | Servonnet, Alice | |
dc.contributor.author | Khoo, Shaun Yon-Seng | |
dc.date.accessioned | 2021-07-08T13:52:32Z | |
dc.date.available | MONTHS_WITHHELD:12 | fr |
dc.date.available | 2021-07-08T13:52:32Z | |
dc.date.issued | 2021-07-05 | |
dc.identifier.uri | http://hdl.handle.net/1866/25338 | |
dc.publisher | Springer | fr |
dc.subject | Instrumental conditioning | fr |
dc.subject | Pavlovian conditioning | fr |
dc.subject | Pavlovian-to-instrumental transfer | fr |
dc.subject | Basolateral amygdala | fr |
dc.subject | Glutamate | fr |
dc.subject | mGlu2/3 receptors | fr |
dc.title | Metabotropic group II glutamate receptors in the basolateral amygdala mediate cue-triggered increases in incentive motivation | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Département de neurosciences | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Département de pharmacologie et physiologie | fr |
dc.identifier.doi | 10.1007/s00213-021-05907-7 | |
dcterms.abstract | Rationale: Reward-associated cues can trigger incentive motivation for reward and invigorate reward-seeking behaviour via Pavlovian-to-instrumental transfer (PIT). Glutamate signaling within the basolateral amygdala (BLA) modulates cue-triggered increases in incentive motivation. However, the role of BLA metabotropic group II glutamate (mGlu2/3) receptors is largely unknown. Objectives: In Experiment 1, we characterized cue-triggered increases in incentive motivation for water reward using the PIT paradigm. In Experiment 2, we assessed the influence of intra-BLA microinjections of the mGlu2/3 receptor agonist LY379268 on this effect. Methods: Water-restricted male Sprague-Dawley rats learned to press a lever for water. Separately, they learned to associate one of two auditory cues with free water. On test days, rats could lever press under extinction conditions (no water), with intermittent, non-contingent CS+ and CS- presentations. In Experiment 1, rats were tested under baseline conditions. In Experiment 2, rats received intra-BLA microinjections of LY379268 (0, 3 and 6 [Formula: see text]g/hemisphere) before testing. Results: Across experiments, CS+, but not CS-, presentations increased water-associated lever pressing during testing, even though responding was reinforced neither by water nor the CS+. Intra-BLA LY379268 abolished both CS+ potentiated pressing on the water-associated lever and CS+ evoked conditioned approach to the site of water delivery. LY379268 did not influence locomotion or instrumental and Pavlovian response rates during intervals between CS presentations or during the CS-, indicating no motor effects. Conclusions: mGlu2/3 receptor activity in the BLA mediates cue-triggered potentiation of incentive motivation for reward, suppressing both cue-induced increases in instrumental pursuit of the reward and anticipatory approach behaviour. | fr |
dcterms.isPartOf | urn:ISSN:0033-3158 | fr |
dcterms.isPartOf | urn:ISSN:1432-2072 | fr |
dcterms.language | eng | fr |
dcterms.relation | https://doi.org/10.6084/m9.figshare.13251125 | fr |
UdeM.ReferenceFournieParDeposant | Garceau, C., Samaha, AN., Cordahi, T., Servonnet, A., & Khoo, SYS. (2021). Metabotropic group II glutamate receptors in the basolateral amygdala mediate cue-triggered increases in incentive motivation. Psychopharmacology. https://doi.org/10.1007/s00213-021-05907-7 | fr |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | fr |
oaire.citationTitle | Psychopharmacology | fr |
Files in this item
This item appears in the following Collection(s)
This document disseminated on Papyrus is the exclusive property of the copyright holders and is protected by the Copyright Act (R.S.C. 1985, c. C-42). It may be used for fair dealing and non-commercial purposes, for private study or research, criticism and review as provided by law. For any other use, written authorization from the copyright holders is required.