Show item record

dc.contributor.authorKhoo, Shaun Yon-Seng
dc.contributor.authorUhrig, Alexandra
dc.contributor.authorSamaha, Anne-Noël
dc.contributor.authorChaudhri, Nadia
dc.date.accessioned2021-04-06T14:02:51Z
dc.date.availableMONTHS_WITHHELD:18fr
dc.date.available2021-04-06T14:02:51Z
dc.date.issued2021-03-17
dc.identifier.urihttp://hdl.handle.net/1866/24952
dc.publisherElsevierfr
dc.subjectAutoshapingfr
dc.subjectPavlovian conditioned approachfr
dc.subjectSign-trackingfr
dc.subjectSCH-23390fr
dc.subjectEticlopridefr
dc.subjectAmphetaminefr
dc.titleEffects of dopamine receptor antagonism and amphetamine-induced psychomotor sensitization on sign- and goal-tracking after extended trainingfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté de médecine. Département de pharmacologie et physiologiefr
dc.identifier.doi10.1016/j.bbr.2021.113238
dcterms.abstractThe dopamine system is important for incentive salience attribution, where motivational value is assigned to conditioned cues that predict appetitive reinforcers. However, the role of dopamine in this process may change with extended training. We tested the effects of dopamine D1-like and D2-like receptor antagonism on the expression of sign-tracking and goal-tracking conditioned responses following extended Pavlovian conditioned approach (PCA) training. We also tested if amphetamine-induced psychomotor sensitization accelerates the enhanced acquisition of sign-tracking that is observed with extended training. In experiment 1, 24 male Long-Evans rats received 20 PCA sessions in which one lever (CS+, 10 s) predicted 0.2 ml sucrose (10 %, w/v) delivery and the other lever (CS–) did not. SCH-23390 (D1-like antagonist) or eticlopride (D2-like antagonist) were administered before non-reinforced behavioural tests at doses of 0, 0.01, and 0.1 mg/kg (s.c.). In experiment 2, rats received vehicle or 2 mg/kg amphetamine (i.p.) for 7 days (n = 12/group). Ten days later, they received 16 PCA training sessions. Both doses of SCH-23390 reduced sign- and goal-tracking, but also reduced locomotor behaviour. A low dose of eticlopride (0.01 mg/kg) selectively reduced goal-tracking, without affecting sign-tracking or locomotor behaviour. Amphetamine produced psychomotor sensitization, and this did not affect the acquisition of sign- or goal-tracking. Following extended PCA training, dopamine D2-like receptor activity is required for the expression of goal-tracking but not sign-tracking. Psychomotor sensitization to amphetamine did not impact incentive salience attribution; however, more selective manipulations of the dopamine system may be needed.fr
dcterms.isPartOfurn:ISSN:0166-4328fr
dcterms.languageengfr
dcterms.relationhttps://doi.org/10.6084/m9.figshare.7571813.v2fr
UdeM.ReferenceFournieParDeposant10.1016/j.bbr.2021.113238fr
UdeM.VersionRioxxVersion acceptée / Accepted Manuscriptfr
oaire.citationTitleBehavioural brain researchfr
oaire.citationVolume407fr


Files in this item

PDF
Under embargo until: 2022-09-17

This item appears in the following Collection(s)

Show item record