Albumin dialysis : a new therapeutic strategy for intoxication from protein-bound drugs
dc.contributor.author | Sen, Sambit | |
dc.contributor.author | Ytrebø, Lars M. | |
dc.contributor.author | Rose, Christopher | |
dc.contributor.author | Fuskevaag, Ole-Martin | |
dc.contributor.author | Davies, Nathan A. | |
dc.contributor.author | Nedredal, Geir I. | |
dc.contributor.author | Williams, Roger | |
dc.contributor.author | Revhaug, Arthur | |
dc.contributor.author | Jalan, Rajiv | |
dc.date.accessioned | 2020-11-11T14:11:28Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2020-11-11T14:11:28Z | |
dc.date.issued | 2004-01-21 | |
dc.identifier.uri | http://hdl.handle.net/1866/24039 | |
dc.publisher | Springer | fr |
dc.subject | Albumin dialysis | fr |
dc.subject | Charcoal | fr |
dc.subject | Adsorption | fr |
dc.subject | Midazolam | fr |
dc.subject | Fentanyl | fr |
dc.title | Albumin dialysis : a new therapeutic strategy for intoxication from protein-bound drugs | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Département de médecine | fr |
dc.identifier.doi | 10.1007/s00134-003-2141-0 | |
dcterms.abstract | Abstract Objective: Although water-soluble drugs can be removed by haemofiltration/haemodialysis, morbidity and mortality from intoxication with protein-bound drugs remains high. The present study investigates whether albumin dialysis in the form of the Molecular Adsorbents Recirculating System (MARS) is effective in removal of protein-bound drugs. Design: Prospective animal study. Setting: Surgical research laboratory in a university hospital. Subjects: Seven female Norwegian Landrace pigs. Intervention: We studied whether midazolam (97% albuminbound) and fentanyl (85% alpha-1- acid glycoprotein-bound), administered as anaesthetics to pigs with induced acute liver failure, could be removed by MARS dialysis lasting for 4 h. Measurements: After 4 h of dialysis, total and free anaesthetic concentrations were measured in the blood and dialysate from different segments of the MARS circuit. Main results: Midazolam: total plasma concentrations fell by 47.1€2.1% (in 4 h) across the MARS filter (p<0.01). The charcoal component of the system reduced the total dialysate drug concentration by 16.4€2.2% (p<0.05). Free midazolam removal followed a similar pattern. Fentanyl: total plasma concentrations fell by 56.1€2.4% (in 4 h) across the MARS filter (p<0.01). Clearance of fentanyl from the dialysate by the charcoal was 70€0.7% at 4 h (p<0.001). Conclusions: The results of the study show that MARS can remove both albumin and other protein-bound drugs efficiently from the plasma, and it may have a place for the treatment of patients suffering from intoxication with this class of compounds. | fr |
dcterms.isPartOf | urn:ISSN:0342-4642 | fr |
dcterms.isPartOf | urn:ISSN:1432-1238 | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | http://dx.doi.org/10.1007/s00134-003-2141-0 | fr |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | fr |
oaire.citationTitle | Intensive care medicine | fr |
oaire.citationVolume | 30 | fr |
oaire.citationStartPage | 496 | fr |
oaire.citationEndPage | 501 | fr |
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