Abstract(s)
There is a need for an alternative to human donor corneas as the availability of good-quality tissues remains limited, with this situation
potentially worsening as the population in many countries is progressively ageing. There have been numerous attempts to develop
corneal equivalent as alternatives to donated human corneas as well as prostheses. In this short review, we focus on the efforts in
bioengineering implants that promote regeneration by Canadian researchers, including our current team of authors. The examples of
technologies developed that we describe include biomaterials that allow for partial regeneration of corneal tissue, self-assembled cornea
constructs and cell-free corneal implants that promoted regeneration when evaluated in clinical trials in Europe.