Show item record

dc.contributor.authorBosoi, Cristina R.
dc.contributor.authorMacedo de Oliveira, Mariana
dc.contributor.authorOchoa-Sanchez, Rafael
dc.contributor.authorTremblay, Mélanie
dc.contributor.authorTen Have, Gabriella A.
dc.contributor.authorDeutz, Nicolaas E. P.
dc.contributor.authorRose, Christopher
dc.contributor.authorBémeur, Chantal
dc.date.accessioned2020-01-03T16:20:32Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2020-01-03T16:20:32Z
dc.date.issued2016-12
dc.identifier.urihttp://hdl.handle.net/1866/22933
dc.publisherSpringerfr
dc.subjectAmmoniafr
dc.subjectExperimental cirrhosisfr
dc.subjectHepatic encephalopathyfr
dc.subjectMuscle mass lossfr
dc.subjectProtein synthesisfr
dc.titleThe bile duct ligated rat : a relevant model to study muscle mass loss in cirrhosisfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté de médecine. Département de médecinefr
dc.contributor.affiliationUniversité de Montréal. Faculté de médecine. Département de nutritionfr
dc.identifier.doi10.1007/s11011-016-9937-4
dcterms.abstractMuscle mass loss and hepatic encephalopathy (complex neuropsychiatric disorder) are serious complications of chronic liver disease (cirrhosis) which impact negatively on clinical outcome and quality of life and increase mortality. Liver disease leads to hyperammonemia and ammonia toxicity is believed to play a major role in the pathogenesis of hepatic encephalopathy. However, the effects of ammonia are not brain-specific and therefore may also affect other organs and tissues including muscle. The precise pathophysiological mechanisms underlying muscle wasting in chronic liver disease remains to be elucidated. In the present study, we characterized body composition as well as muscle protein synthesis in cirrhotic rats with hepatic encephalopathy using the 6-week bile duct ligation (BDL) model which recapitulates the main features of cirrhosis. Compared to sham-operated control animals, BDL rats display significant decreased gain in body weight, altered body composition, decreased gastrocnemius muscle mass and circumference as well as altered muscle morphology. Muscle protein synthesis was also significantly reduced in BDL rats compared to control animals. These findings demonstrate that the 6-week BDL experimental rat is a relevant model to study liver disease-induced muscle mass loss.fr
dcterms.isPartOfurn:ISSN:0885-7490fr
dcterms.isPartOfurn:ISSN:1573-7365fr
dcterms.languageengfr
UdeM.ReferenceFournieParDeposantBosoi, C. R., Oliveira, M. M., Ochoa-Sanchez, R., Tremblay, M., Ten Have, G. A., Deutz, N. E., Rose, C.F. and Bemeur, C. (2017). The bile duct ligated rat : A relevant model to study muscle mass loss in cirrhosis. Metabolic Brain Disease, 32(2), 513‑518. https://doi.org/10.1007/s11011-016-9937-4fr
UdeM.VersionRioxxVersion acceptée / Accepted Manuscriptfr
oaire.citationTitleMetabolic brain disease
oaire.citationVolume32
oaire.citationIssue2
oaire.citationStartPage513
oaire.citationEndPage518


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show item record

This document disseminated on Papyrus is the exclusive property of the copyright holders and is protected by the Copyright Act (R.S.C. 1985, c. C-42). It may be used for fair dealing and non-commercial purposes, for private study or research, criticism and review as provided by law. For any other use, written authorization from the copyright holders is required.