Platelet function in aging
dc.contributor.author | Le Blanc, Jessica | |
dc.contributor.author | Lordkipanidzé, Marie | |
dc.date.accessioned | 2019-10-15T19:37:31Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2019-10-15T19:37:31Z | |
dc.date.issued | 2019-08-07 | |
dc.identifier.uri | http://hdl.handle.net/1866/22386 | |
dc.publisher | Frontiers Media | fr |
dc.subject | Platelet function | fr |
dc.subject | Aging | fr |
dc.subject | Senescence | fr |
dc.subject | Elderly | fr |
dc.subject | Cardiovascular disease | fr |
dc.subject | Thrombosis | fr |
dc.title | Platelet function in aging | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de pharmacie | fr |
dc.identifier.doi | 10.3389/fcvm.2019.00109 | |
dcterms.abstract | Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that platelet aggregability is increased in vascular diseases, the contribution of age-related changes in platelet biology to cardiovascular risk is not well-understood. Several lines of evidence support that platelets from older subjects differ in their function and structure, making platelets more prone to activation and less sensitive to inhibition. These age-related changes could lead to platelet hyperactivity and to the development of a prothrombotic state in advanced age. This review will focus on platelet biochemical modifications during aging and on the mechanisms by which these alterations could lead to thrombotic disease. | fr |
dcterms.isPartOf | urn:ISSN:2297-055X | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | PMID: 31448291 | fr |
UdeM.VersionRioxx | Version publiée / Version of Record | fr |
oaire.citationTitle | Frontiers in cardiovascular medicine | |
oaire.citationVolume | 6 |
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