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Clinical importance of thrombocytopenia in patients with acute coronary syndromes : a systematic review and meta-analysis

dc.contributor.authorDiscepola, Vanessa
dc.contributor.authorSchnitzer, Mireille
dc.contributor.authorJolicoeur, Marc
dc.contributor.authorRousseau, Guy
dc.contributor.authorLordkipanidzé, Marie
dc.date.accessioned2018-10-29T18:42:32Z
dc.date.availableMONTHS_WITHHELD:12fr
dc.date.available2018-10-29T18:42:32Z
dc.date.issued2018-10-22
dc.identifier.urihttp://hdl.handle.net/1866/21035
dc.publisherTaylor & Francisfr
dc.subjectAcute coronary syndromefr
dc.subjectBleedingfr
dc.subjectIschemiafr
dc.subjectMajor adverse cardiac eventsfr
dc.subjectMortalityfr
dc.subjectThrombocytopeniafr
dc.titleClinical importance of thrombocytopenia in patients with acute coronary syndromes : a systematic review and meta-analysisfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté de médecinefr
dc.contributor.affiliationUniversité de Montréal. Faculté de pharmaciefr
dc.identifier.doi10.1080/09537104.2018.1528348
dcterms.abstractThrombocytopenia (TP) is common in hospitalized patients. In the context of acute coronary syndromes (ACS), TP has been linked to adverse clinical outcomes. We present a systematic review and meta-analysis of the evidence on the clinical importance of pre-existing and in-hospital acquired TP in the context of ACS. Specifically, we address (a) the prevalence and associated factors with TP in the context of ACS; and (b) the association between TP and all-cause mortality, major adverse cardiovascular events (MACE) and major bleeding. We conducted systematic literature searches in MEDLINE and Web of Science. For the meta-analysis, we fit linear mixed models with a random study-specific intercept for the aggregate outcomes. A total of 16 studies and 190,915 patients were included in this study. Of these patients, 8.8% ± 1.2% presented with pre-existing TP while 5.8% ± 1.0% developed TP after hospital admission. Pre-existing TP was not statistically significantly associated with adverse outcomes. Acquired TP was associated with greater risk of all-cause mortality (risk difference (RD): 4.3%; 95% confidence interval (CI): 2% - 6%; p=0.04), MACE (RD: 8.5%; 95% CI: 1% -16.0%; p=0.037) and major bleeding (RD: 11.9%; 95% CI: 5% - 19%; p=0.005). In conclusion, TP is a prevalent condition in patients admitted for an ACS and identifies a high-risk patient population more likely to experience ischemic and bleeding complications, as well as higher mortality.fr
dcterms.alternativeThrombocytopenia in acute coronary syndromesfr
dcterms.isPartOfurn:ISSN:0953-7104fr
dcterms.isPartOfurn:ISSN:1369-1635fr
dcterms.languageengfr
UdeM.ReferenceFournieParDeposantClinical importance of thrombocytopenia in patients with acute coronary syndromes: a systematic review and meta-analysis. Discepola V, Schnitzer ME, Jolicoeur EM, Rousseau G, Lordkipanidzé M. Platelets. 2018 Oct 22:1-11. doi: 10.1080/09537104.2018.1528348.fr
UdeM.VersionRioxxVersion acceptée / Accepted Manuscriptfr
oaire.citationTitlePlatelets


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