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dc.contributor.authorBourque, Josiane
dc.contributor.authorSpechler, Philip A.
dc.contributor.authorPotvin, Stéphane
dc.contributor.authorWhelan, Robert
dc.contributor.authorBanaschewski, Tobias
dc.contributor.authorBokde, Arun W. L.
dc.contributor.authorBromberg, Uli
dc.contributor.authorBüchel, Christian
dc.contributor.authorBurke Quinlan, Erin
dc.contributor.authorConrod, Patricia
dc.date.accessioned2018-09-28T18:19:33Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2018-09-28T18:19:33Z
dc.date.issued2017-06-01
dc.identifier.urihttp://hdl.handle.net/1866/20951
dc.publisherAmerican Psychiatric Publishingfr
dc.subjectAdolescentsfr
dc.subjectBrain imaging techniquesfr
dc.subjectMood disorders-bipolarfr
dc.subjectPsychosisfr
dc.titleFunctional neuroimaging predictors of self-reported psychotic symptoms in adolescentsfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté de médecine. Département de psychiatriefr
dc.identifier.doi10.1176/appi.ajp.2017.16080897
dcterms.abstractOBJECTIVE: This study investigated the neural correlates of psychotic-like experiences in youths during tasks involving inhibitory control, reward anticipation, and emotion processing. A secondary aim was to test whether these neurofunctional correlates of risk were predictive of psychotic symptoms 2 years later. METHOD: Functional imaging responses to three paradigms-the stop-signal, monetary incentive delay, and faces tasks-were collected in youths at age 14, as part of the IMAGEN study. At baseline, youths from London and Dublin sites were assessed on psychotic-like experiences, and those reporting significant experiences were compared with matched control subjects. Significant brain activity differences between the groups were used to predict, with cross-validation, the presence of psychotic symptoms in the context of mood fluctuation at age 16, assessed in the full sample. These prediction analyses were conducted with the London-Dublin subsample (N=246) and the full sample (N=1,196). RESULTS: Relative to control subjects, youths reporting psychotic-like experiences showed increased hippocampus/amygdala activity during processing of neutral faces and reduced dorsolateral prefrontal activity during failed inhibition. The most prominent regional difference for classifying 16-year-olds with mood fluctuation and psychotic symptoms relative to the control groups (those with mood fluctuations but no psychotic symptoms and those with no mood symptoms) was hyperactivation of the hippocampus/amygdala, when controlling for baseline psychotic-like experiences and cannabis use. CONCLUSIONS: The results stress the importance of the limbic network's increased response to neutral facial stimuli as a marker of the extended psychosis phenotype. These findings might help to guide early intervention strategies for at-risk youths.fr
dcterms.bibliographicCitationAmerican Journal of Psychiatry ; vol. 174, no 6, p. 566-575fr
dcterms.isPartOfurn:ISSN:0002-953Xfr
dcterms.isPartOfurn:ISSN:1535-7228fr
dcterms.languageengfr
UdeM.ReferenceFournieParDeposantBourque, J., Spechler, P. A., Potvin, S., ..., Conrod, P. & IMAGEN Consortium. (2017) Functional neuroimaging predictors of self-reported psychotic symptoms in adolescents [Online]. American Journal of Psychiatry, -.fr
UdeM.VersionRioxxVersion publiée / Version of Recordfr


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