3D Cohort Study : The Integrated Research Network in Perinatology of Quebec and Eastern Ontario
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Paediatric and perinatal epidemiology ; vol. 30, no. 6, pp. 623-632.Publisher(s)
WileyAuthor(s)
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Abstract(s)
Background: The 3D Cohort Study (Design, Develop, Discover) was established to help bridge knowledge gaps
about the links between various adverse exposures during pregnancy with birth outcomes and later health
outcomes in children.
Methods: Pregnant women and their partners were recruited during the first trimester from nine sites in Quebec
and followed along with their children through to 2 years of age. Questionnaires were administered during
pregnancy and post-delivery to collect information on demographics, mental health and life style, medical history,
psychosocial measures, diet, infant growth, and neurodevelopment. Information on the delivery and newborn
outcomes were abstracted from medical charts. Biological specimens were collected from mothers during each
trimester, fathers (once during the pregnancy), and infants (at delivery and 2 years of age) for storage in a
biological specimen bank.
Results: Of the 9864 women screened, 6348 met the eligibility criteria and 2366 women participated in the study
(37% of eligible women). Among women in the 3D cohort, 1721 of their partners (1704 biological fathers) agreed to
participate (73%). Two thousand two hundred and nineteen participants had a live singleton birth (94%). Prenatal
blood and urine samples as well as vaginal secretions were collected for ≥98% of participants, cord blood for 81%
of livebirths, and placental tissue for 89% of livebirths.
Conclusions: The 3D Cohort Study combines a rich bank of multiple biological specimens with extensive clinical,
life style, and psychosocial data. This data set is a valuable resource for studying the developmental etiology of
birth and early childhood neurodevelopmental outcomes.
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