The role of the melanoma gene MC1R in Parkinson disease and REM sleep behavior disorder
dc.contributor.author | Gan-Or, Ziv | |
dc.contributor.author | Mohsin, Noreen | |
dc.contributor.author | Girard, Simon L. | |
dc.contributor.author | Montplaisir, Jacques-Yves | |
dc.contributor.author | Ambalavanan, Amirthagowri | |
dc.contributor.author | Strong, Stephanie | |
dc.contributor.author | Mallett, Victoria | |
dc.contributor.author | Laurent, Sandra B. | |
dc.contributor.author | Bourassa, Cynthia V. | |
dc.contributor.author | Boivin, Michel | |
dc.contributor.author | Langlois, Melanie | |
dc.contributor.author | Arnulf, Isabelle | |
dc.contributor.author | Högl, Birgit | |
dc.contributor.author | Frauscher, Birgit | |
dc.contributor.author | Monaca, Christelle | |
dc.contributor.author | Desautels, Alex | |
dc.contributor.author | Gagnon, Jean-François | |
dc.contributor.author | Postuma, Ronald B. | |
dc.contributor.author | Dion, Patrick A. | |
dc.contributor.author | Dauvilliers, Yves | |
dc.contributor.author | Dupré, Nicolas | |
dc.contributor.author | Alcalay, Roy N. | |
dc.contributor.author | Rouleau, Guy | |
dc.date.accessioned | 2018-09-07T18:05:55Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2018-09-07T18:05:55Z | |
dc.date.issued | 2016-07 | |
dc.identifier.uri | http://hdl.handle.net/1866/20863 | |
dc.publisher | Elsevier | fr |
dc.subject | Genetics | fr |
dc.subject | MC1R | fr |
dc.subject | Melanoma | fr |
dc.subject | Parkinson disease | fr |
dc.title | The role of the melanoma gene MC1R in Parkinson disease and REM sleep behavior disorder | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Département de psychiatrie et d'addictologie | fr |
dc.identifier.doi | 10.1016/j.neurobiolaging.2016.03.029 | |
dcterms.abstract | The MC1R gene, suggested to be involved in Parkinson disease (PD) and melanoma, was sequenced in PD patients (n=539) and controls (n=265) from New-York, and PD patients (n=551), rapid eye movement sleep behavior disorder (RBD) patients (n=351) and controls (n=956) of European ancestry. Sixty-eight MC1R variants were identified, including 7 common variants with frequency>0.01. None of the common variants was associated with PD or RBD in the different regression models. In a meta-analysis with fixed-effect model, the p.R160W variant was associated with an increased risk for PD (OR=1.22, 95%CI 1.02-1.47, p=0.03) but with significant heterogeneity (p=0.048). Removing one study that introduced the heterogeneity resulted in nonsignificant association (OR=1.11, 95%CI 0.92-1.35, p=0.27, heterogeneity p=0.57). Rare variants had similar frequencies in patients and controls (10.54% and 10.15%, respectively, p=0.75), and no cumulative effect of carrying more than one MC1R variant was found. The current study does not support a role for the MC1R p.R160W and other variants in susceptibility for PD or RBD. | fr |
dcterms.isPartOf | urn:ISSN:0197-4580 | fr |
dcterms.isPartOf | urn:ISSN:1558-1497 | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | Gran-Or, Z., Mohsin, N., Girard, S. L., Montplaisir, J. Y., Ambalavanan, A., Strong, S., ..., Boivin, M. & Rouleau, G. A. (2016) The role of the melanoma gene MC1R in Parkinson disease and REM sleep behavior disorder. Neurobiology of Aging, 43, 180.e7-180.e13. | fr |
UdeM.VersionRioxx | Version publiée / Version of Record | fr |
oaire.citationTitle | Neurobiology of aging | |
oaire.citationVolume | 43 | |
oaire.citationStartPage | 180.e7 | |
oaire.citationEndPage | 180.e13 |
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