Show item record

dc.contributor.authorElkin, Igor
dc.contributor.authorBanquy, Xavier
dc.contributor.authorBarrett, Christopher J.
dc.contributor.authorHildgen, Patrice
dc.date.accessioned2018-04-25T18:18:11Z
dc.date.availableMONTHS_WITHHELD:12fr
dc.date.available2018-04-25T18:18:11Z
dc.date.issued2017-09-06
dc.identifier.urihttp://hdl.handle.net/1866/19944
dc.publisherElsevierfr
dc.subjectDendrimerfr
dc.subjectActive principlefr
dc.subjectNon-covalent dendrimer-drug-associationfr
dc.subjectDrug-formulationfr
dc.subjectPhysico-chemical mechanismsfr
dc.subjectBio-distributionfr
dc.subjectBiosafetyfr
dc.titleNon-covalent formulation of active principles with dendrimers: current state-of-the-art and prospects for further developmentfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté de pharmaciefr
UdeM.statutProfesseur(e) / Professorfr
dc.identifier.doi10.1016/j.jconrel.2017.09.002
dcterms.abstractDuring the last three decades, dendrimers, nano-sized highly-branched fractal-like symmetrical macromolecules, have been intensively studied as promising candidates for application as drug-delivery carriers. Among other important characteristics arising from their unique and highly-controlled architecture, size and surface properties, the possibility of hosting guest molecules in internal voids represents a key advantage underlying the potential of dendrimers as non-covalent drug-encapsulating agents. The impressive amount of accumulating experimental results to date allows researchers to identify the most important and promising theoretical and practical aspects of the use of dendrimers for this purpose. This review covers the main factors, phenomena, and mechanisms involved in this drug-vectorization approach, including mechanisms of non-covalent dendrimer-drug association, dendrimer-dendrimer interactions, as well as biological properties relevant to the host dendrimers. A discussion is then provided to illustrate some successful existing formulation strategies as well as to propose some new possible ones to optimize further development of the field.fr
dcterms.isPartOfurn:ISSN:0168-3659
dcterms.isPartOfurn:ISSN:1873-4995
dcterms.languageengfr
UdeM.VersionRioxxVersion acceptée / Accepted Manuscriptfr
oaire.citationTitleJournal of controlled release
oaire.citationVolume264
oaire.citationStartPage288
oaire.citationEndPage305


Files in this item

Microsoft Word

This item appears in the following Collection(s)

Show item record