Parcourir Faculté de médecine – Travaux et publications par sujet "Lactate"
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Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure
(2007-12)We previously demonstrated in pigs with acute liver failure (ALF) that albumin dialysis using the molecular adsorbents recirculating system (MARS) attenuated a rise in intracranial pressure (ICP). This was independent of changes in arterial ammonia, ... -
Elevated cerebral lactate : implications in the pathogenesis of hepatic encephalopathy
(Springer, 2014-06-11)Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome, is a frequent complication of liver failure/disease. Increased concentrations of lactate are commonly observed in HE patients, in the systemic circulation, but also in the brain. ... -
Increase brain lactate in hepatic encephalopathy: Cause or consequence?
(2010-11)Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome which develops as a result of liver failure or disease. Increased concentrations of brain lactate (microdialysate, cerebrospinal fluid, tissue) are commonly measured in patients with ... -
Increased brain lactate is central to the development of brain edema in rats with chronic liver disease
(2014)The pathogenesis of brain edema in patients with chronic liver disease (CLD) and minimal hepatic encephalopathy (HE) remains undefined. This study evaluated the role of brain lactate, glutamine and organic osmolytes, including myo-inositol and taurine, ... -
Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects
(2002-12)Mild hypothermia (32 degrees C-35 degrees C) reduces intracranial pressure in patients with acute liver failure and may offer an effective adjunct therapy in the management of these patients. Studies in experimental animals suggest that this beneficial ... -
Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure
(2001-06)Evidence from both clinical and experimental studies demonstrates that mild hypothermia prevents encephalopathy and brain edema in acute liver failure (ALF). As part of a series of studies to elucidate the mechanism(s) involved in this protective effect, ...