Browsing Faculté de médecine – Travaux et publications by Subject "Autophagy"

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  • Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes 

    Beillevaire, Déborah; Migneault, Francis; Turgeon, Julie; Gingras, Diane; Karakeussian Rimbaud, Annie; Marcoux, Geneviève; Spino, Crysta; Thibodeau-Jarry, Nicolas; Bonneil, Eric; Thibault, Pierre; Boilard, Éric; Dieudé, Mélanie; Hébert, Marie-Josée (Springer Nature, 2022-02-11)
    Apoptotic exosome-like vesicles (ApoExos) are a novel type of extracellular vesicle that contribute to the propagation of inflammation at sites of vascular injury when released by dying cells. ApoExos are characterized by the presence of the C-terminal ...

  • Autophagy drives fibroblast senescence through MTORC2 regulation 

    Autophagy, senescence and myofibroblast differentiation
    Bernard, Monique; Yang, Bing; Migneault, Francis; Turgeon, Julie; Dieudé, Mélanie; Olivier, Marc-Alexandre; Cardin, Guillaume B.; El-Diwany, Mostafa; Underwood, Katy; Rodier, Francis; Hébert, Marie-Josée (Taylor & Francis, 2020-01-13)
    Sustained macroautophagy/autophagy favors the differentiation of fibroblasts into myofibroblasts. Cellular senescence, another means of responding to long-term cellular stress, has also been linked to myofibroblast differentiation and fibrosis. Here, ...