Browsing Faculté de médecine – Travaux et publications by Author "Nikiforuk, Agnieszka"

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  • Distinct cognitive and discriminative stimulus effects of ketamine enantiomers in rats 

    Popik, Piotr; Khoo, Shaun Yon-Seng; Kuziak, Agata; Golebiowska, Joanna; Potasiewicz, Agnieszka; Hogendorf, Adam; Popik, Oskar; Matloka, Mikolaj; Moszczynski, Rafal; Nikiforuk, Agnieszka; Witkin, Jeffrey M. (Elsevier, 2020-08-03)
    Although (S)-ketamine was approved for use in treatment-resistant depression in 2019, new preclinical findings suggest that (R)-ketamine might produce better efficacy and tolerability relative to (S)-ketamine. Here we evaluated the effects of (R)-, ...

  • Efects of ketamine optical isomers, psilocybin, psilocin and norpsilocin on time estimation and cognition in rats 

    Popik, Piotr; Hogendorf, Adam; Bugno, Ryszard; Shaun Yon-Seng, Khoo; Zajdel, Pawel; Malikowska‑Racia, Natalia; Nikiforuk, Agnieszka; Golebiowska, Joanna (Springer, 2022-03-02)
    Rationale Ketamine and psilocybin belong to the rapid-acting antidepressants but they also produce psychotomimetic efects including timing distortion. It is currently debatable whether these are essential for their therapeutic actions. As depressed patients ...