Browsing Faculté de médecine – Travaux et publications by Author "Jiang, Wenlei"

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  • Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress 

    Yang, Xiaoling; Bosoi, Cristina R.; Jiang, Wenlei; Tremblay, Mélanie; Rose, Christopher (2010-03)
    Ammonia is neurotoxic and believed to play a major role in the pathogenesis of hepatic encephalopathy (HE). It has been demonstrated, in vitro and in vivo, that acute and high ammonia treatment induces oxidative stress. Reactive oxygen species (ROS) ...

  • Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure 

    Bosoi, Cristina R.; Yang, Xiaoling; Huynh, Jimmy; Parent-Robitaille, Christian; Jiang, Wenlei; Tremblay, Mélanie; Rose, Christopher (2012-04)
    Chronic liver failure leads to hyperammonemia, a central component in the pathogenesis of hepatic encephalopathy (HE); however, a correlation between blood ammonia levels and HE severity remains controversial. It is believed oxidative stress plays a ...