Browsing Faculté de médecine – Travaux et publications by Author "Jalan, Rajiv"
Now showing items 1-13 of 13
-
Albumin dialysis : a new therapeutic strategy for intoxication from protein-bound drugs
Sen, Sambit; Ytrebø, Lars M.; Rose, Christopher; Fuskevaag, Ole-Martin; Davies, Nathan A.; Nedredal, Geir I.; Williams, Roger; Revhaug, Arthur; Jalan, Rajiv (Springer, 2004-01-21)Abstract Objective: Although water-soluble drugs can be removed by haemofiltration/haemodialysis, morbidity and mortality from intoxication with protein-bound drugs remains high. The present study investigates whether albumin dialysis in the form of ... -
Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure
Rose, Christopher; Ytrebø, Lars M.; Davies, Nathan A.; Sen, Sambit; Nedredal, Geir I.; Bélanger, Mireille; Jalan, Rajiv; Revhaug, Arthur (2007-12)We previously demonstrated in pigs with acute liver failure (ALF) that albumin dialysis using the molecular adsorbents recirculating system (MARS) attenuated a rise in intracranial pressure (ICP). This was independent of changes in arterial ammonia, ... -
Congenital glutamine deficiency with glutamine synthetase mutations
Rose, Christopher; Jalan, Rajiv (2006-03) -
Contractile response of femoral arteries in pigs with acute liver failure
Ytrebø, Lars M.; Ekse, Sveinung; Sen, Sambit; Rose, Christopher; Nedredal, Geir I.; Fuskevåg, Ole-Martin; Jalan, Rajiv; Revhaug, Arthur (2004)BACKGROUND: Acute liver failure (ALF) is characterized haemodynamically by a progressive hyperdynamic circulation. The pathophysiological mechanism is unknown, but impaired contractility of vascular smooth muscle may play an important role. The aim of ... -
Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study
Sen, Sambit; Rose, Christopher; Ytrebø, Lars M.; Davies, Nathan A.; Nedredal, Geir I.; Drevland, Synnøve S.; Kjønnø, Marianne; Prinzen, Frits W.; Hodges, Stephen J.; Deutz, Nicolaas E. P.; Williams, Roger; Butterworth, Roger; Revhaug, Arthur; Jalan, Rajiv (2006-01)BACKGROUND: Increased intracranial pressure (ICP) worsens the outcome of acute liver failure (ALF). This study investigates the underlying pathophysiological mechanisms and evaluates the therapeutic effect of albumin dialysis in ALF with use of the ... -
Erroneous ammonia measurement is not synonymous with a lack of efficacy of ammonia-lowering therapies in hepatic encephalopathy
Rose, Christopher; Jalan, Rajiv; Shawcross, Debbie L. (Elsevier, 2021-01-29) -
Hepatic encephalopathy : novel insights into classification, pathophysiology and therapy
Rose, Christopher; Amodio, Piero; Bajaj, Jasmohan S.; Dhiman, Radha Krishan; Montagnese, Sara; Taylor-Robinson, Simon D.; Vilstrup, Hendrik; Jalan, Rajiv (Elsevier, 2020-10-21)Hepatic encephalopathy (HE) is a frequent and serious complication of both chronic liver disease and acute liver failure. HE manifests as a wide spectrum of neuropsychiatric abnormalities, from subclinical changes (mild cognitive impairment) to marked ... -
Heretical thoughts into hepatic encephalopathy
Jalan, Rajiv; Rose, Christopher (Elsevier & European Association for the Study of the Liver, 2022-03-27)Clinical progress in the development of new diagnostic modalities and therapeutic strategies for the management of patients with hepatic encephalopathy has lagged behind the vast knowledge that has been generated from basic studies. In this article, ... -
Hypothermia in acute liver failure
Jalan, Rajiv; Rose, Christopher (2004)The development of encephalopathy in patients with acute liver injury defines the occurrence of liver failure. The encephalopathy of acute liver failure is characterized by brain edema which manifests clinically as increased intracranial pressure. ... -
Judging the value of ammonia measurement on lactulose dosing : apples and oranges?
Rose, Christopher; Jalan, Rajiv (University of Toronto Press, 2021-02-24) -
L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure
Ytrebø, Lars M.; Kristiansen, Rune; Maehre, Hanne; Fuskevåg, Ole-Martin; Kalstad, Trine; Revhaug, Arthur; Jalan, Rajiv; Rose, Christopher (2009-07)Hyperammonemia is a feature of acute liver failure (ALF), which is associated with increased intracranial pressure (ICP) and brain herniation. We hypothesized that a combination of L-ornithine and phenylacetate (OP) would synergistically reduce toxic ... -
Lessons on brain edema in HE : from cellular to animal models and clinical studies
Pierzchala, Katarzyna; Hadjihambi, Anna; Mosso, Jessie; Jalan, Rajiv; Rose, Christopher; Cudalbu, Cristina (Springer, 2023-08-22)Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE and its implication in the development of the neurological alterations linked to HE are still under debate. ... -
Systemic and regional hemodynamics in pigs with acute liver failure and the effect of albumin dialysis
Ytrebø, Lars M.; Sen, Sambit; Rose, Christopher; Davies, Nathan A.; Nedredal, Geir I.; Fuskevåg, Ole-Martin; Have Gabrie, A. M. Ten; Prinzen, Frits W.; Williams, Roger; Deutz, Nicolaas E. P.; Jalan, Rajiv; Revhaug, Arthur (2006)OBJECTIVE: Acute liver failure (ALF) is haemodynamically characterized by a hyperdynamic circulation. The aims of this study were to investigate the systemic and regional haemodynamics in ALF, to measure changes in nitric oxide metabolites (NOx) and ...