Browsing Faculté de médecine – Travaux et publications by Author "Jackson, Andrew P."

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  • Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma 

    Tamayo-Orrego, Lukas; Gallo, David; Racicot, Frédéric; Bemmo, Amandine; Mohan, Sushmetha; Ho, Brandon; Salameh, Samer; Hoang, Trang; Jackson, Andrew P.; Brown, Grant W.; Charron, Frédéric (Nature Research, 2020-07-20)
    The mechanisms generating cancer-initiating mutations are not well understood. Sonic hedgehog (SHH) pathway activation is frequent in medulloblastoma (MB), with PTCH1 mutations being a common initiating event. Here we investigated the role of the ...