Browsing Faculté de médecine – Travaux et publications by Author "Dashwood, Amy"

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  • Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits 

    Whyte, Carly E.; Singh, Kailash; Burton, Oliver T.; Aloulou, Meryem; Kouser, Lubna; Veiga, Rafael Valente; Dashwood, Amy; Okkenhaug, Hanneke; Benadda, Samira; Moudra, Alena; Bricard, Orian; Lienart, Stephanie; Bielefeld, Pascal; Roca, Carlos P.; Naranjo-Galindo, Francisco José; Lombard-Vadnais, Félix; Junius, Steffie; Bending, David; Ono, Masahiro; Hochepied, Tino; Halim, Timotheus Y. F.; Schlenner, Susan; Lesage, Sylvie; Dooley, James; Liston, Adrian (Rockefeller University Press, 2022-06-14)
    Interleukin 2 (IL-2) is a key homeostatic cytokine, with therapeutic applications in both immunogenic and tolerogenic immune modulation. Clinical use has been hampered by pleiotropic functionality and widespread receptor expression, with unexpected adverse ...