Parcourir Faculté de médecine – Travaux et publications par sujet "Cardiac electrophysiology"
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Fitting local repolarization parameters in cardiac reaction-diffusion models in the presence of electrotonic coupling
(Elsevier, 2017)Background: Repolarization gradients contribute to arrhythmogenicity. In reaction–diffusion models of cardiac tissue, heterogeneities in action potential duration (APD) can be created by locally modifying an intrinsic membrane kinetics parameter. ... -
Modeling atrial arrhythmias : impact on clinical diagnosis and therapies
(Institute of electrical and electronics engineers, 2008)Atrial arrhythmias are the most frequent sustained rhythm disorders in humans and often lead to severe complications such as heart failure and stroke. Despite the important insights provided by animal models into the mechanisms of atrial arrhythmias, ... -
Modeling left and right atrial contributions to the ECG : a dipole-current source approach
(Elsevier, 2015)This paper presents the mathematical formulation, the numerical validation and several illustrations of a forward-modeling approach based on dipole-current sources to compute the contribution of a part of the heart to the electrocardiogram (ECG). ... -
Phase singularity detection through phase map interpolation : theory, advantages and limitations
(Elsevier, 2018-07-24)Background During a cardiac arrhythmia, reentrant waves rotate around critical points called phase singularities (PS). PS detection is relevant to the quantitative description of the dynamics and to the identification of potential targets for ablation. ... -
A simple analytical model of action potential duration profile in electrotonically-coupled cells
(Elsevier, 2016)Electrotonic interactions between cardiac cells modulate the dispersion of action potential duration (APD). This paper provides a complete mathematical analysis of a simple model of exponential-shaped repolarization in a network of electrotonically-coupled ... -
Steady-state solutions in mathematical models of atrial cell electrophysiology and their stability
(Elsevier, 2006-11-10)The steady states of the Fenton–Karma, the Courtemanche and the Nygren cell models were studied by determining the fixed points of the dynamical system describing their cell kinetics. The linear stability of the fixed points was investigated, as well ...