Parcourir Faculté de médecine – Travaux et publications par sujet "Calcium channel"
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Functional characterization of CaVα2δ mutations associated with sudden cardiac death
(Elsevier, 2015-01-30)L-type Ca(2+) channels play a critical role in cardiac rhythmicity. These ion channels are oligomeric complexes formed by the pore-forming CaVα1 with the auxiliary CaVβ and CaVα2δ subunits. CaVα2δ increases the peak current density and improves the ... -
Identification of glycosylation sites essential for surface expression of the Caᵥα2δ1 subunit and modulation of the Cardiac Caᵥ1.2 channel activity
(Elsevier, 2016-02-26)Alteration in the L-type current density is one aspect of the electrical remodeling observed in patients suffering from cardiac arrhythmias. Changes in channel function could result from variations in the protein biogenesis, stability, post-translational ...