Parcourir Faculté de médecine – Travaux et publications par sujet "Brain edema"
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Brain edema : a valid endpoint for measuring hepatic encephalopathy?
(2016-06)Hepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease. This metabolic neuropsychiatric syndrome involves a spectrum of symptoms, including cognition ... -
Brain edema in acute liver failure and chronic liver disease: Similarities and differences
(2013)Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome that typically develops as a result of acute liver failure or chronic liver disease. Brain edema is a common feature associated with HE. In acute liver failure, brain edema contributes ... -
Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure
(2006-06)BACKGROUND/AIMS: It has been proposed that, in acute liver failure, skeletal muscle adapts to become the principle organ responsible for removal of blood-borne ammonia by increasing glutamine synthesis, a reaction that is catalyzed by the cytosolic ... -
Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study
(2003)Mild hypothermia has a protective effect on brain edema and encephalopathy in both experimental and human acute liver failure. The goals of the present study were to examine the effects of mild hypothermia (35°C) on brain metabolic pathways using ... -
Elevated cerebral lactate : implications in the pathogenesis of hepatic encephalopathy
(Springer, 2014-06-11)Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome, is a frequent complication of liver failure/disease. Increased concentrations of lactate are commonly observed in HE patients, in the systemic circulation, but also in the brain. ... -
Increased brain lactate is central to the development of brain edema in rats with chronic liver disease
(2014)The pathogenesis of brain edema in patients with chronic liver disease (CLD) and minimal hepatic encephalopathy (HE) remains undefined. This study evaluated the role of brain lactate, glutamine and organic osmolytes, including myo-inositol and taurine, ... -
Keeping cool in acute liver failure: rationale for the use of mild hypothermia
(2005)Encephalopathy, brain edema and intracranial hypertension are neurological complications responsible for substantial morbidity/mortality in patients with acute liver failure (ALF), where, aside from liver transplantation, there is currently a paucity ... -
Lessons on brain edema in HE : from cellular to animal models and clinical studies
(Springer, 2023-08-22)Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE and its implication in the development of the neurological alterations linked to HE are still under debate. ... -
Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure
(2001)There is increasing evidence that central noradrenaline (NA) transport mechanisms are implicated in the central nervous system complications of acute liver failure. In order to assess this possibility, binding sites for the high affinity NA transporter ... -
Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects
(2002-12)Mild hypothermia (32 degrees C-35 degrees C) reduces intracranial pressure in patients with acute liver failure and may offer an effective adjunct therapy in the management of these patients. Studies in experimental animals suggest that this beneficial ... -
Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure
(2005-05)BACKGROUND/AIMS: Mild hypothermia has proven useful in the clinical management of patients with acute liver failure. Acute liver failure in experimental animals results in alterations in the expression of genes coding for astrocytic proteins including ... -
Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure
(2001-06)Evidence from both clinical and experimental studies demonstrates that mild hypothermia prevents encephalopathy and brain edema in acute liver failure (ALF). As part of a series of studies to elucidate the mechanism(s) involved in this protective effect, ... -
Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia
(2004)The principal cause of mortality in patients with acute liver failure (ALF) is brain herniation resulting from intracranial hypertension caused by a progressive increase of brain water. In the present study, ex vivo high-resolution 1H-NMR spectroscopy ... -
Sex is associated with differences in oxidative stress and susceptibility to severe hepatic encephalopathy in bile-duct ligated rats
(Wiley, 2022-06-30)Hepatic encephalopathy (HE) is a debilitating neurological complication of chronic liver disease (CLD). Hyperammonemia plays an important role in HE’s pathogenesis, acting synergistically with systemic oxidative stress. During CLD, muscle plays a ...