Parcourir Faculté de médecine – Travaux et publications par sujet "Action potential duration"
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Fitting local repolarization parameters in cardiac reaction-diffusion models in the presence of electrotonic coupling
(Elsevier, 2017)Background: Repolarization gradients contribute to arrhythmogenicity. In reaction–diffusion models of cardiac tissue, heterogeneities in action potential duration (APD) can be created by locally modifying an intrinsic membrane kinetics parameter. ... -
In silico human cardiomyocyte action potential modeling : exploring ion channel input combinations
(SAGE, 2024-03-13)In silico modeling offers an opportunity to supplement and accelerate cardiac safety testing. With in silico modeling, computational simulation methods are used to predict electrophysiological interactions and pharmacological effects of novel drugs on ... -
A simple analytical model of action potential duration profile in electrotonically-coupled cells
(Elsevier, 2016)Electrotonic interactions between cardiac cells modulate the dispersion of action potential duration (APD). This paper provides a complete mathematical analysis of a simple model of exponential-shaped repolarization in a network of electrotonically-coupled ...