Parcourir Faculté de médecine – Travaux et publications par auteur·e "Parent-Robitaille, Christian"
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AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile duct-ligated rats
Bosoi, Cristina R.; Parent-Robitaille, Christian; Anderson, Keith; Tremblay, Mélanie; Rose, Christopher (2011)The pathogenesis of hepatic encephalopathy is multifactorial, involving gut-derived toxins such as ammonia, which has been demonstrated to induce oxidative stress. Therefore, a primary hepatic encephalopathy treatment target is reducing ammonia production ... -
Increased brain lactate is central to the development of brain edema in rats with chronic liver disease
Bosoi, Cristina R.; Zwingmann, Claudia; Marin, Helen A.; Parent-Robitaille, Christian; Huynh, Jimmy; Tremblay, Mélanie; Rose, Christopher (2014)The pathogenesis of brain edema in patients with chronic liver disease (CLD) and minimal hepatic encephalopathy (HE) remains undefined. This study evaluated the role of brain lactate, glutamine and organic osmolytes, including myo-inositol and taurine, ... -
Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure
Bosoi, Cristina R.; Yang, Xiaoling; Huynh, Jimmy; Parent-Robitaille, Christian; Jiang, Wenlei; Tremblay, Mélanie; Rose, Christopher (2012-04)Chronic liver failure leads to hyperammonemia, a central component in the pathogenesis of hepatic encephalopathy (HE); however, a correlation between blood ammonia levels and HE severity remains controversial. It is believed oxidative stress plays a ...