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Drug-loaded nanocarriers : passive targeting and crossing of biological barriers
(2012-12)
Poor bioavailability and poor pharmacokinetic characteristics are some of the leading causes of drug development failure. Therefore, poorly-soluble drugs, fragile proteins or nucleic acid products may benefit from their ...
Factors associated with psychotropic drug use among community-dwelling older persons: A review of empirical studies
(2004)
BACKGROUND:In the many descriptive studies on prescribed psychotropic drug use by community-dwelling older persons, several sociodemographic and other factors associated with drug use receive inconsistent support.METHOD:Empirical ...
Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo
(2004)
BACKGROUND:From in vitro studies, it has become clear that several signaling cascades are involved in angiotensin II-induced cellular hypertrophy. The aim of the present study was to determine some of the signaling pathways ...
Clinical importance of thrombocytopenia in patients with acute coronary syndromes : a systematic review and meta-analysis
Thrombocytopenia in acute coronary syndromes
(Taylor & Francis, 2018-10-22)
Thrombocytopenia (TP) is common in hospitalized patients. In the context of acute coronary syndromes (ACS), TP has been linked to adverse clinical outcomes. We present a systematic review and meta-analysis of the evidence ...
Assessment of PEG on Polymeric Particles Surface, a Key Step in Drug Carrier Translation
(2014-07)
Injectable drug nanocarriers have greatly benefited in their clinical development from the addition of a superficial hydrophilic corona to improve their cargo pharmacokinetics. The most studied and used polymer for this ...
Superswelling microneedle arrays for dermal interstitial fluid (prote) omics
(Wiley, 2021-08-16)
The noninvasive sampling of dermal interstitial fluid (ISF) for the monitoring of clinical biomarkers is a greatly appealing area of research. The identification of molecular biomarkers in biological fluids has been ...
Sonochemical synthesis of porous gold nano- and micro-particles in a Rosette cell for drug delivery applications
Sonochemical synthesis of porous gold nano- and microparticles in a Rosette cell
(Elsevier, 2021-09-05)
We report the synthesis of gold nano- and micro-particles that relies on α-D-glucose (C6H12O6) as the reducer and stabilizer in a Rosette cell under 20 kHz ultrasound irradiation. The chemical and physical effects of ...
De la mesure au sens de la mesure : l’économie scripturaire du sida et de son traitement en République centrafricaine (RCA)
(Société d'Anthropologie des Connaissances, 2016-06-30)
Pour donner sens à la mesure, il faut la rapporter à un système de valeurs qui en permet l’évaluation et le jugement. Voilà le parti pris théorique qui sous-tend cet article consacré aux pratiques d’écriture de la lutte ...
The relational dimensions of pharmaceutical care : experience from caring for HIV-infected asylum seekers in Montréal
(Elsevier, 2019-09-03)
By describing the experience from dispensing antiretroviral drugs to asylum seekers infected with HIV in Montreal we argue for the relational dimensions of pharmaceutical care. Between 2010 and 2016, the Government of ...
Nanoparticle shell structural cues drive in vitro transport properties, tissue distribution and brain accessibility in Zebrafish
(Elsevier, 2021-08-24)
Zwitterion polymers with strong antifouling properties have been suggested as the prime alternative to polyethylene glycol (PEG) for drug nanocarriers surface coating. It is believed that PEG coating shortcomings, such as ...