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Unified scaling of the structure and loading of nanoparticles formed via diffusion-limited coalescence
(American Chemical Society, 2018-04-30)
The present study establishes the scaling laws describing the structure of spherical nanoparticles formed by diffusion-limited coalescence. We produced drug-loaded nanoparticles from a poly(ethylene glycol)-poly(d,l-lactic ...
Biomimetic bottle-brush polymer coatings for fabrication of ultra-low fouling surfaces
(Wiley, 2018-11-13)
The increasing demand for long lasting antifouling surfaces has steered the development of accessible, novel, biocompatible and environmentally-friendly materials. Inspired by lubricin (LUB), a component of mammalian ...
Modeling treatment effect modification in multidrug-resistant tuberculosis in an individual patient data meta-analysis
(SAGE, 2021)
Effect modification occurs while the effect of the treatment is not homogeneous across the different strata of patient characteristics. When the effect of treatment may vary from individual to individual, precision medicine ...
Acetylcholinesterase inhibitors and risk of bleeding and acute ischemic events in non-hypertensive Alzheimer’s patients
(2021-08-20)
Introduction: Acetylcholinesterase inhibitors (AChEIs) are commonly used to treat
mild to moderate cases of Alzheimer disease (AD). To the best of our knowledge, there
has been no study estimating the risk of bleeding ...
Assessing cardiometabolic parameter monitoring in inpatients taking a second-generation antipsychotic : the CAMI-SGA study – a crosssectional study
(BMJ Publishing Group, 2022)
Objectives This study aims to determine the proportion
of initial cardiometabolic assessment and its predicting
factors in adults with schizophrenia, bipolar disorder or
other related diagnoses for whom a second-gener ...
Lubrication and wear protection of micro-structured hydrogels using bioinspired fluids
(American Chemical Society, 2018-11-21)
We report the fabrication and the use of a bioinspired synovial fluid acting as a lubricant fluid
and anti-wear agent at soft and porous chitosan hydrogel tribopairs. This synthetic synovial
fluid is composed of sodium ...
Implications of the antiplatelet therapy gap left with discontinuation of prasugrel in Canada
(Elsevier, 2020-12-16)
Background
The current Canadian Cardiovascular Society antiplatelet therapy guidelines recommend the use of ticagrelor or prasugrel over clopidogrel as first-line platelet P2Y12 receptor antagonists for treatment of ...
(In)stability of ligands at the surface of inorganic nanoparticles : a forgotten question in nanomedicine?
(Elsevier, 2022-06-14)
Multiple inorganic nanoparticles (NPs) are currently being developed for nanomedicine. Various core materials and shapes are explored, but they all display a common hybrid structure, with organic ligands on their surface. ...
Interaction forces between pegylated star-shaped polymers at mica surfaces
(American Chemical Society, 2017-08-03)
We present a study focused on characterizing the interaction forces between mica surfaces across solutions containing star-shaped polymers with cationic ends. Using the Surface Forces Apparatus, we show that the interaction ...
Effect of surface chemistry of polymeric nanoparticles on cutaneous penetration of cholecalciferol
(Elsevier, 2018-10-11)
We investigated the influence of nanoparticle (NP) surface composition on different aspects of skin delivery of a lipophilic drug: chemical stability, release and skin penetration. Cholecalciferol was chosen as a labile ...