Browsing Faculté de pharmacie – Travaux et publications by Author "Welman, Mélanie"
Now showing items 1-6 of 6
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Brain-derived neurotrophic factor mitigates the association between platelet dysfunction and cognitive impairment
Bélanger, Jean-Christophe; Bouchard, Véronique; Le Blanc, Jessica; Starnino, Louisia; Welman, Mélanie; Chabot-Blanchet, Malorie; Busseuil, David; Chertkow, Howard; D'Antono, Bianca; Lordkipanidzé, Marie (Frontiers media, 2021-09-07)Background: Platelet hyperactivity is deleterious in coronary artery disease (CAD), requiring lifelong antiplatelet therapy, and is associated with worse cognitive outcomes. Upon activation, platelets release Brain-Derived Neurotrophic Factor (BDNF), ... -
The brain-derived neurotrophic factor prompts platelet aggregation and secretion
Boukhatem, Imane; Fleury, Samuel; Welman, Mélanie; Le Blanc, Jessica; Thys, Chantal; Freson, Kathleen; Best, Myron G.; Würdinger, Thomas; Allen, Bruce G.; Lordkipanidzé, Marie (American Society of Hematology, 2021-09-21)Brain-derived neurotrophic factor (BDNF) has both autocrine and paracrine roles in neurons, and its release and signaling mechanisms have been extensively studied in the central nervous system. Large quantities of BDNF have been reported in ... -
Clinical correlates identify ProBDNF and thrombo-inflammatory markers as key predictors of circulating p75NTR extracellular domain levels in older adults
Fleury, Samuel; Schnitzer, Mireille; Ledoux-Hutchinson, Lawrence; Boukhatem, Imane; Bélanger, Jean-Christophe; Welman, Mélanie; Busseuil, David; Tardif, Jean-Claude; D’Antono, Bianca; Lordkipanidzé, Marie (Frontiers Media, 2022-02-21)The p75NTR receptor binds all neurotrophins and is mostly known for its role in neuronal survival and apoptosis. Recently, the extracellular domain (ECD) of p75NTR has been reported in plasma, its levels being dysregulated in numerous neurological ... -
Head‐to‐Head comparison of consensus‐recommended platelet function tests to assess P2Y12 Inhibition : insights for multi‐center trials
Bélanger, Jean‐Christophe; Bandeira Ferreira, Fabio Luiz; Welman, Mélanie; Boulahya, Rahma; Tanguay, Jean‐François; So, Derek Y. F.; Lordkipanidzé, Marie (MDPI, 2020)The vasodilator‐associated stimulated phosphoprotein (VASP) phosphorylation level is a highly specific method to assess P2Y12 receptor inhibition. Traditionally, VASP phosphorylation is analyzed by flow cytometry, which is laborious and restricted ... -
Platelets selectively regulate the release of BDNF, but not that of its precursor protein, proBDNF
Le Blanc, Jessica; Fleury, Samuel; Boukhatem, Imane; Bélanger, Jean‐Christophe; Welman, Mélanie; Lordkipanidzé, Marie (Frontiers Media, 2020-11-25)Background: Brain-derived neurotrophic factor (BDNF) plays a role in synaptic plasticity and neuroprotection. BDNF has well-established pro-survival effects, whereas its precursor protein, proBDNF, induces apoptosis. Thus, it has been suggested that ... -
Tissue-specificity of antibodies raised against TrkB and p75NTR receptors ; implications for platelets as models of neurodegenerative diseases
Fleury, Samuel; Boukhatem, Imane; Le Blanc, Jessica; Welman, Mélanie; Lordkipanidzé, Marie (Frontiers media, 2021-02-11)Platelets and neurons share many similarities including comparable secretory granule types with homologous calcium-dependent secretory mechanisms as well as internalization, sequestration and secretion of many neurotransmitters. Thus, platelets present ...