Browsing Faculté de pharmacie – Travaux et publications by Author "Ramassamy, Charles"
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Deep tissue penetration of bottle-brush polymers via cell capture evasion and fast diffusion
Rabanel, Jean-Michel; Mirbagheri, Marziye; Olszewski, Mateusz; Xie, Guojun; Le Goas, Marine; Latreille, Pierre-Luc; Counil, Hermine; Hervé, Vincent; Oliveira Silva, Rummenigge; Zaouter, Charlotte; Adibnia, Vahid; Acevedo, Mariana; Servant, Marc; Martinez, Vincent A.; Patten, Shunmoogum A.; Matyjaszewski, Krzysztof; Ramassamy, Charles; Banquy, Xavier (American Chemical Society, 2022-12-14)Drug nanocarriers (NCs) capable of crossing the vascular endothelium and deeply penetrating into dense tissues of the CNS could potentially transform the management of neurological diseases. In the present study, we investigated the interaction of ... -
Effect of polymer architecture on Curcumin 1 encapsulation and release from PEGylated polymer nanoparticles: toward a drug delivery nano-platform to the CNS
Rabanel, Jean-Michel; Faivre, Jimmy; Djiokeng Paka, Ghislain; Ramassamy, Charles; Hildgen, Patrice; Banquy, Xavier (2015-10-01)We developed a nanoparticles (NPs) library from poly(ethylene glycol)–poly lactic acid comb-like polymers with variable amount of PEG. Curcumin was encapsulated in the NPs with a view to develop a delivery platform to treat diseases involving oxidative ... -
Nanoparticle heterogeneity : an emerging structural parameter 2 influencing particle fate in biological media?
Rabanel, Jean-Michel; Adibnia, Vahid; Tehrani, Soudeh F.; Sanche, Steven; Hildgen, Patrice; Banquy, Xavier; Ramassamy, Charles (Royal Society of Chemistry, 2018-11-27)Drug nanocarriers’ surface chemistry is often presumed to be uniform. For instance, the polymer surface coverage and distribution of ligands on nanoparticles are described with averaged values obtained from quantification techniques based on particle ... -
Nanoparticle shell structural cues drive in vitro transport properties, tissue distribution and brain accessibility in Zebrafish
Rabanel, Jean-Michel; Faivre, Jimmy; Zaouter, Charlotte; Patten, Shunmoogum A.; Banquy, Xavier; Ramassamy, Charles (Elsevier, 2021-08-24)Zwitterion polymers with strong antifouling properties have been suggested as the prime alternative to polyethylene glycol (PEG) for drug nanocarriers surface coating. It is believed that PEG coating shortcomings, such as immune responses and incomplete ...