Browsing Faculté de pharmacie – Travaux et publications by Author "Lalloz, Augustine"

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  • Effect of Polymer Architecture on the Structural and Biophysical Properties of PEG-PLA Nanoparticles 

    Rabanel, Jean-Michel; Faivre, Jimmy; Tehrani, Soudeh F.; Lalloz, Augustine; Hildgen, Patrice; Banquy, Xavier (2015-05-01)
    Polymers made of poly(ethylene glycol) chains grafted to poly(lactic acid) chains (PEG-g-PLA) were used to produce stealth drug nanocarriers. A library of comb-like PEG-g-PLA polymers with different PEG grafting densities was prepared in order to obtain ...

  • Effect of surface chemistry of polymeric nanoparticles on cutaneous penetration of cholecalciferol 

    Lalloz, Augustine; Bolzinger, Marie-Alexandrine; Faivre, Jimmy; Latreille, Pierre-Luc; García Ac, Araceli; Rakotovao, Cyrielle; Rabanel, Jean-Michel; Hildgen, Patrice; Banquy, Xavier; Briançon, Stéphanie (Elsevier, 2018-10-11)
    We investigated the influence of nanoparticle (NP) surface composition on different aspects of skin delivery of a lipophilic drug: chemical stability, release and skin penetration. Cholecalciferol was chosen as a labile model drug. Poly(lactic acid) ...

  • Subtle and unexpected role of PEG in tuning the penetration mechanisms of PLA-based nano-formulations into intact and impaired skin 

    Lalloz, Augustine; Bolzinger, Marie-Alexandrine; Briançon, Stéphanie; Faivre, Jimmy; Rabanel, Jean-Michel; García Ac, Araceli; Hildgen, Patrice; Banquy, Xavier (Elsevier, 2019-02-27)
    We present a systematic study of the role of poly(ethylene glycol) (PEG) content in NPs on drug skin absorption. Cholecalciferol-loaded NPs of 100 nm of diameter were prepared by flash nanoprecipitation from PLA-b-PEG copolymers of various PEG lengths. ...

  • Unified scaling of the structure and loading of nanoparticles formed via diffusion-limited coalescence 

    Rode García, Teresita; García Ac, Araceli; Lalloz, Augustine; Lacasse, Francois-Xavier; Hildgen, Patrice; Rabanel, Jean-Michel; Banquy, Xavier (American Chemical Society, 2018-04-30)
    The present study establishes the scaling laws describing the structure of spherical nanoparticles formed by diffusion-limited coalescence. We produced drug-loaded nanoparticles from a poly(ethylene glycol)-poly(d,l-lactic acid) diblock polymer (PEG-b-PLA) ...