Browsing Faculté de pharmacie – Travaux et publications by Author "García Ac, Araceli"

Now showing items 1-5 of 5

  • Effect of surface chemistry of polymeric nanoparticles on cutaneous penetration of cholecalciferol 

    Lalloz, Augustine; Bolzinger, Marie-Alexandrine; Faivre, Jimmy; Latreille, Pierre-Luc; García Ac, Araceli; Rakotovao, Cyrielle; Rabanel, Jean-Michel; Hildgen, Patrice; Banquy, Xavier; Briançon, Stéphanie (Elsevier, 2018-10-11)
    We investigated the influence of nanoparticle (NP) surface composition on different aspects of skin delivery of a lipophilic drug: chemical stability, release and skin penetration. Cholecalciferol was chosen as a labile model drug. Poly(lactic acid) ...

  • Quantification of peptides in human synovial fluid using liquid chromatography–tandem mass spectrometry 

    García Ac, Araceli; Duy, Sung Vo; Sauvé, Sébastien; Moldovan, Florina; Roullin, Valérie Gaëlle (Elsevier, 2018-04-06)
    A method to explore the stability of two anti-inflammatory peptides in human synovial fluid (HSF) has been developed and validated using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The two peptides are BQ123 Cyclo(-D-Trp-D-A ...

  • A quantitative UHPLC-MS/MS method for the growth hormone-releasing peptide-6 determination in complex biological matrices and transdermal formulations 

    A quantitative UPLC-MS/MS method for the growth hormone-releasing peptide-6 determination in complex biological matrices and transdermal formulations
    Esposito, Cloé; García Ac, Araceli; Laszlo, Elise; Duy, Sung Vo; Michaud, Catherine; Sauvé, Sébastien; Ong, Huy; Marleau, Sylvie; Banquy, Xavier; Brambilla, Davide (Elsevier, 2021-05-26)
    Growth hormone-releasing peptide-6 (GHRP-6) is part of a group of small synthetic peptides with potent GH-releasing activity that have gained attention in the last two decades by virtue of their cyto- and cardioprotective effects. Despite numerous ...

  • Subtle and unexpected role of PEG in tuning the penetration mechanisms of PLA-based nano-formulations into intact and impaired skin 

    Lalloz, Augustine; Bolzinger, Marie-Alexandrine; Briançon, Stéphanie; Faivre, Jimmy; Rabanel, Jean-Michel; García Ac, Araceli; Hildgen, Patrice; Banquy, Xavier (Elsevier, 2019-02-27)
    We present a systematic study of the role of poly(ethylene glycol) (PEG) content in NPs on drug skin absorption. Cholecalciferol-loaded NPs of 100 nm of diameter were prepared by flash nanoprecipitation from PLA-b-PEG copolymers of various PEG lengths. ...

  • Unified scaling of the structure and loading of nanoparticles formed via diffusion-limited coalescence 

    Rode García, Teresita; García Ac, Araceli; Lalloz, Augustine; Lacasse, Francois-Xavier; Hildgen, Patrice; Rabanel, Jean-Michel; Banquy, Xavier (American Chemical Society, 2018-04-30)
    The present study establishes the scaling laws describing the structure of spherical nanoparticles formed by diffusion-limited coalescence. We produced drug-loaded nanoparticles from a poly(ethylene glycol)-poly(d,l-lactic acid) diblock polymer (PEG-b-PLA) ...