Browsing Faculté de pharmacie – Travaux et publications by Author "Boukhatem, Imane"
Now showing items 1-5 of 5
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The brain-derived neurotrophic factor prompts platelet aggregation and secretion
Boukhatem, Imane; Fleury, Samuel; Welman, Mélanie; Le Blanc, Jessica; Thys, Chantal; Freson, Kathleen; Best, Myron G.; Würdinger, Thomas; Allen, Bruce G.; Lordkipanidzé, Marie (American Society of Hematology, 2021-09-21)Brain-derived neurotrophic factor (BDNF) has both autocrine and paracrine roles in neurons, and its release and signaling mechanisms have been extensively studied in the central nervous system. Large quantities of BDNF have been reported in ... -
Clinical correlates identify ProBDNF and thrombo-inflammatory markers as key predictors of circulating p75NTR extracellular domain levels in older adults
Fleury, Samuel; Schnitzer, Mireille; Ledoux-Hutchinson, Lawrence; Boukhatem, Imane; Bélanger, Jean-Christophe; Welman, Mélanie; Busseuil, David; Tardif, Jean-Claude; D’Antono, Bianca; Lordkipanidzé, Marie (Frontiers Media, 2022-02-21)The p75NTR receptor binds all neurotrophins and is mostly known for its role in neuronal survival and apoptosis. Recently, the extracellular domain (ECD) of p75NTR has been reported in plasma, its levels being dysregulated in numerous neurological ... -
Platelets selectively regulate the release of BDNF, but not that of its precursor protein, proBDNF
Le Blanc, Jessica; Fleury, Samuel; Boukhatem, Imane; Bélanger, Jean‐Christophe; Welman, Mélanie; Lordkipanidzé, Marie (Frontiers Media, 2020-11-25)Background: Brain-derived neurotrophic factor (BDNF) plays a role in synaptic plasticity and neuroprotection. BDNF has well-established pro-survival effects, whereas its precursor protein, proBDNF, induces apoptosis. Thus, it has been suggested that ... -
Postoperative administration of the acetylcholinesterase inhibitor, donepezil, interferes with bone healing and implant osseointegration in a rat model
Al-Hamed, Faez Saleh; Maria, Ola M.; Phan, Jeff; Al Subaie, Ahmed; Gao, Qiman; Mansour, Alaa; Abu Nada, Lina; Boukhatem, Imane; Elkashty, Osama A.; Tran, Simon D.; Lordkipanidzé, Marie; Badran, Zahi; Tamimi, Faleh (MDPI, 2020-09-14)Donepezil is an acetylcholinesterase inhibitor commonly used to treat mild to moderate Alzheimer’s disease. Its use has been associated with increased bone mass in humans and animals. However, the effect of postoperative administration of donepezil on ... -
Tissue-specificity of antibodies raised against TrkB and p75NTR receptors ; implications for platelets as models of neurodegenerative diseases
Fleury, Samuel; Boukhatem, Imane; Le Blanc, Jessica; Welman, Mélanie; Lordkipanidzé, Marie (Frontiers media, 2021-02-11)Platelets and neurons share many similarities including comparable secretory granule types with homologous calcium-dependent secretory mechanisms as well as internalization, sequestration and secretion of many neurotransmitters. Thus, platelets present ...