Parcourir Faculté de pharmacie – Travaux et publications par auteur·e "Bélanger, Jean-Christophe"

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Brain-derived neurotrophic factor mitigates the association between platelet dysfunction and cognitive impairment

Bélanger, Jean-Christophe; Bouchard, Véronique; Le Blanc, Jessica; Starnino, Louisia; Welman, Mélanie; Chabot-Blanchet, Malorie; Busseuil, David; Chertkow, Howard; D'Antono, Bianca; Lordkipanidzé, Marie (Frontiers media, 2021-09-07)

Background: Platelet hyperactivity is deleterious in coronary artery disease (CAD), requiring lifelong antiplatelet therapy, and is associated with worse cognitive outcomes. Upon activation, platelets release Brain-Derived Neurotrophic Factor (BDNF), ...
Clinical correlates identify ProBDNF and thrombo-inflammatory markers as key predictors of circulating p75NTR extracellular domain levels in older adults

Fleury, Samuel; Schnitzer, Mireille; Ledoux-Hutchinson, Lawrence; Boukhatem, Imane; Bélanger, Jean-Christophe; Welman, Mélanie; Busseuil, David; Tardif, Jean-Claude; D’Antono, Bianca; Lordkipanidzé, Marie (Frontiers Media, 2022-02-21)

The p75NTR receptor binds all neurotrophins and is mostly known for its role in neuronal survival and apoptosis. Recently, the extracellular domain (ECD) of p75NTR has been reported in plasma, its levels being dysregulated in numerous neurological ...