Browsing Faculté de pharmacie – Travaux et publications by Author "Bélanger, Jean‐Christophe"
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Head‐to‐Head comparison of consensus‐recommended platelet function tests to assess P2Y12 Inhibition : insights for multi‐center trials
Bélanger, Jean‐Christophe; Bandeira Ferreira, Fabio Luiz; Welman, Mélanie; Boulahya, Rahma; Tanguay, Jean‐François; So, Derek Y. F.; Lordkipanidzé, Marie (MDPI, 2020)The vasodilator‐associated stimulated phosphoprotein (VASP) phosphorylation level is a highly specific method to assess P2Y12 receptor inhibition. Traditionally, VASP phosphorylation is analyzed by flow cytometry, which is laborious and restricted ... -
Platelets selectively regulate the release of BDNF, but not that of its precursor protein, proBDNF
Le Blanc, Jessica; Fleury, Samuel; Boukhatem, Imane; Bélanger, Jean‐Christophe; Welman, Mélanie; Lordkipanidzé, Marie (Frontiers Media, 2020-11-25)Background: Brain-derived neurotrophic factor (BDNF) plays a role in synaptic plasticity and neuroprotection. BDNF has well-established pro-survival effects, whereas its precursor protein, proBDNF, induces apoptosis. Thus, it has been suggested that ...