Browsing Faculté de pharmacie – Travaux et publications by Author "Rabanel, Jean-Michel"
Now showing items 1-11 of 11
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Assessment of PEG on Polymeric Particles Surface, a Key Step in Drug Carrier Translation
Rabanel, Jean-Michel; Hildgen, Patrice; Banquy, Xavier (2014-07)Injectable drug nanocarriers have greatly benefited in their clinical development from the addition of a superficial hydrophilic corona to improve their cargo pharmacokinetics. The most studied and used polymer for this purpose is poly(ethylene glycol), ... -
Deep tissue penetration of bottle-brush polymers via cell capture evasion and fast diffusion
Rabanel, Jean-Michel; Mirbagheri, Marziye; Olszewski, Mateusz; Xie, Guojun; Le Goas, Marine; Latreille, Pierre-Luc; Counil, Hermine; Hervé, Vincent; Oliveira Silva, Rummenigge; Zaouter, Charlotte; Adibnia, Vahid; Acevedo, Mariana; Servant, Marc; Martinez, Vincent A.; Patten, Shunmoogum A.; Matyjaszewski, Krzysztof; Ramassamy, Charles; Banquy, Xavier (American Chemical Society, 2022-12-14)Drug nanocarriers (NCs) capable of crossing the vascular endothelium and deeply penetrating into dense tissues of the CNS could potentially transform the management of neurological diseases. In the present study, we investigated the interaction of ... -
Drug-loaded nanocarriers : passive targeting and crossing of biological barriers
Rabanel, Jean-Michel; Aoun, Valery; Elkin, Igor; Mokhtar, Mohamed; Hildgen, Patrice (2012-12)Poor bioavailability and poor pharmacokinetic characteristics are some of the leading causes of drug development failure. Therefore, poorly-soluble drugs, fragile proteins or nucleic acid products may benefit from their encapsulation in nanosized ... -
Effect of polymer architecture on Curcumin 1 encapsulation and release from PEGylated polymer nanoparticles: toward a drug delivery nano-platform to the CNS
Rabanel, Jean-Michel; Faivre, Jimmy; Djiokeng Paka, Ghislain; Ramassamy, Charles; Hildgen, Patrice; Banquy, Xavier (2015-10-01)We developed a nanoparticles (NPs) library from poly(ethylene glycol)–poly lactic acid comb-like polymers with variable amount of PEG. Curcumin was encapsulated in the NPs with a view to develop a delivery platform to treat diseases involving oxidative ... -
Effect of Polymer Architecture on the Structural and Biophysical Properties of PEG-PLA Nanoparticles
Rabanel, Jean-Michel; Faivre, Jimmy; Tehrani, Soudeh F.; Lalloz, Augustine; Hildgen, Patrice; Banquy, Xavier (2015-05-01)Polymers made of poly(ethylene glycol) chains grafted to poly(lactic acid) chains (PEG-g-PLA) were used to produce stealth drug nanocarriers. A library of comb-like PEG-g-PLA polymers with different PEG grafting densities was prepared in order to obtain ... -
Effect of surface chemistry of polymeric nanoparticles on cutaneous penetration of cholecalciferol
Lalloz, Augustine; Bolzinger, Marie-Alexandrine; Faivre, Jimmy; Latreille, Pierre-Luc; García Ac, Araceli; Rakotovao, Cyrielle; Rabanel, Jean-Michel; Hildgen, Patrice; Banquy, Xavier; Briançon, Stéphanie (Elsevier, 2018-10-11)We investigated the influence of nanoparticle (NP) surface composition on different aspects of skin delivery of a lipophilic drug: chemical stability, release and skin penetration. Cholecalciferol was chosen as a labile model drug. Poly(lactic acid) ... -
(In)stability of ligands at the surface of inorganic nanoparticles : a forgotten question in nanomedicine?
Le Goas, Marine; Saber, Justine; González Bolívar, Sara; Rabanel, Jean-Michel; Awogni, Jean-Marc; Boffito, Daria C.; Banquy, Xavier (Elsevier, 2022-06-14)Multiple inorganic nanoparticles (NPs) are currently being developed for nanomedicine. Various core materials and shapes are explored, but they all display a common hybrid structure, with organic ligands on their surface. These ligands play a key role ... -
Nanoparticle heterogeneity : an emerging structural parameter 2 influencing particle fate in biological media?
Rabanel, Jean-Michel; Adibnia, Vahid; Tehrani, Soudeh F.; Sanche, Steven; Hildgen, Patrice; Banquy, Xavier; Ramassamy, Charles (Royal Society of Chemistry, 2018-11-27)Drug nanocarriers’ surface chemistry is often presumed to be uniform. For instance, the polymer surface coverage and distribution of ligands on nanoparticles are described with averaged values obtained from quantification techniques based on particle ... -
Nanoparticle shell structural cues drive in vitro transport properties, tissue distribution and brain accessibility in Zebrafish
Rabanel, Jean-Michel; Faivre, Jimmy; Zaouter, Charlotte; Patten, Shunmoogum A.; Banquy, Xavier; Ramassamy, Charles (Elsevier, 2021-08-24)Zwitterion polymers with strong antifouling properties have been suggested as the prime alternative to polyethylene glycol (PEG) for drug nanocarriers surface coating. It is believed that PEG coating shortcomings, such as immune responses and incomplete ... -
Subtle and unexpected role of PEG in tuning the penetration mechanisms of PLA-based nano-formulations into intact and impaired skin
Lalloz, Augustine; Bolzinger, Marie-Alexandrine; Briançon, Stéphanie; Faivre, Jimmy; Rabanel, Jean-Michel; García Ac, Araceli; Hildgen, Patrice; Banquy, Xavier (Elsevier, 2019-02-27)We present a systematic study of the role of poly(ethylene glycol) (PEG) content in NPs on drug skin absorption. Cholecalciferol-loaded NPs of 100 nm of diameter were prepared by flash nanoprecipitation from PLA-b-PEG copolymers of various PEG lengths. ... -
Unified scaling of the structure and loading of nanoparticles formed via diffusion-limited coalescence
Rode García, Teresita; García Ac, Araceli; Lalloz, Augustine; Lacasse, Francois-Xavier; Hildgen, Patrice; Rabanel, Jean-Michel; Banquy, Xavier (American Chemical Society, 2018-04-30)The present study establishes the scaling laws describing the structure of spherical nanoparticles formed by diffusion-limited coalescence. We produced drug-loaded nanoparticles from a poly(ethylene glycol)-poly(d,l-lactic acid) diblock polymer (PEG-b-PLA) ...