Browsing Faculté de pharmacie – Travaux et publications by Title
Now showing items 70-95 of 95
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Quantification of peptides in human synovial fluid using liquid chromatography–tandem mass spectrometry
(Elsevier, 2018-04-06)A method to explore the stability of two anti-inflammatory peptides in human synovial fluid (HSF) has been developed and validated using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The two peptides are BQ123 Cyclo(-D-Trp-D-A ... -
A quantitative UHPLC-MS/MS method for the growth hormone-releasing peptide-6 determination in complex biological matrices and transdermal formulations
A quantitative UPLC-MS/MS method for the growth hormone-releasing peptide-6 determination in complex biological matrices and transdermal formulations
(Elsevier, 2021-05-26)Growth hormone-releasing peptide-6 (GHRP-6) is part of a group of small synthetic peptides with potent GH-releasing activity that have gained attention in the last two decades by virtue of their cyto- and cardioprotective effects. Despite numerous ... -
A randomized double-blind feasibility study comparing cetirizine and diphenhydramine in the prevention of paclitaxel-associated infusion-related reactions : the PREMED-F1 study
(Springer, 2022-01-08)Purpose. Cetirizine is a less sedative alternative to diphenhydramine for the prevention of infusion-related reactions (IRR) to paclitaxel. However, its use remains controversial. In this study, we assessed feasibility for a future definitive ... -
Rationing hepatitis C treatment in the context of austerity policies in France and Cameroon : a transnational perspective on thepharmaceuticalization of healthcare systems
(Elsevier, 2017-03-28)New powerful drugs against hepatitis C can cure the disease, but they are not widely distributed because their exorbitant prices are destabilizing healthcare systems in both African and European countries. This article takes access to hepatitis C ... -
Recent developments in natural and synthetic polymeric drug delivery systems used for the treatment of osteoarthritis
(Elsevier, 2021-01-12)Osteoarthritis (OA), is a common musculoskeletal disorder that will progressively increase in older populations and is expected to be the most dominant cause of disability in the world population by 2030. The progression of OA is controlled by a ... -
The relational dimensions of pharmaceutical care : experience from caring for HIV-infected asylum seekers in Montréal
(Elsevier, 2019-09-03)By describing the experience from dispensing antiretroviral drugs to asylum seekers infected with HIV in Montreal we argue for the relational dimensions of pharmaceutical care. Between 2010 and 2016, the Government of Canada changed the medical coverage ... -
Release kinetics from nano-inclusion-based and affinity-based hydrogels: A comparative study
(Elsevier, 2017-06-15)In this study, we compare the release mechanisms from nanocomposite hydrogels. Liposomes made of different compositions of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC), nanogels made of ... -
Resistance and mutations of non-specificity in the field of anxietydepressive disorders in Canadian medical journals, 1950-1990
(Elsevier, 2014-12-03)Pharmaceuticalisation is a complex phenomenon, co-constitutive of what scholars identify as a pharmaceutical regime, comprised of networks of actors, institutions and artefacts as well as cognitive structures that underlie the production, promotion ... -
Short-sequence superadhesive peptides with topologically en-hanced cation-π interactions
(American Chemical Society, 2021-06-03)In this study, using the surface force apparatus, we report engineered peptides with short sequences of phenylalanine (F) and lysine (K) amino acids capable of forming the most efficient cation−π interactions reported for underwater adhesive systems ... -
Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo
(2004)BACKGROUND:From in vitro studies, it has become clear that several signaling cascades are involved in angiotensin II-induced cellular hypertrophy. The aim of the present study was to determine some of the signaling pathways mediating angiotensin II ... -
Sonochemical synthesis of porous gold nano- and micro-particles in a Rosette cell for drug delivery applications
Sonochemical synthesis of porous gold nano- and microparticles in a Rosette cell
(Elsevier, 2021-09-05)We report the synthesis of gold nano- and micro-particles that relies on α-D-glucose (C6H12O6) as the reducer and stabilizer in a Rosette cell under 20 kHz ultrasound irradiation. The chemical and physical effects of ultrasonic irradiation on the ... -
Start small : how nanomedicine could alleviate the burden of rare CNS Diseases
(MDPI, 2021-01-30)The complexity and organization of the central nervous system (CNS) is widely modulated by the presence of the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCSFB), which both act as biochemical, dynamic obstacles impeding any ... -
Study of the bioaccumulation of tinzaparin in renally impaired patients when given at prophylactic doses : The STRIP study
Prophylactic tinzaparin in severe renal disease
(Elsevier, 2018-12-02) -
Subtle and unexpected role of PEG in tuning the penetration mechanisms of PLA-based nano-formulations into intact and impaired skin
(Elsevier, 2019-02-27)We present a systematic study of the role of poly(ethylene glycol) (PEG) content in NPs on drug skin absorption. Cholecalciferol-loaded NPs of 100 nm of diameter were prepared by flash nanoprecipitation from PLA-b-PEG copolymers of various PEG lengths. ... -
Superlubricity of zwitterionic bottlebrush polymers in the presence of multivalent ions
(American Chemical Society, 2020-08-13)In this study, we report lubrication properties of physisorbed zwitterionic bottlebrush polymers in the presence of multivalent ions using the surface force apparatus. Unlike polyelectrolyte brushes, the lubrication properties of which diminish drastically ... -
Superswelling microneedle arrays for dermal interstitial fluid (prote) omics
(Wiley, 2021-08-16)The noninvasive sampling of dermal interstitial fluid (ISF) for the monitoring of clinical biomarkers is a greatly appealing area of research. The identification of molecular biomarkers in biological fluids has been accelerated with -omics analyses but ... -
Synergy between zwitterionic polymers and hyaluronic acid enhances antifouling performance
(American Chemical Society, 2019-09-03)Challenges associated with nonspecific adsorption of proteins on sensor surfaces have steered the development of novel antifouling materials and strategies. Inspired by human synovial fluid composition and structure, we designed synergistic antifouling ... -
Tissue-specificity of antibodies raised against TrkB and p75NTR receptors ; implications for platelets as models of neurodegenerative diseases
(Frontiers media, 2021-02-11)Platelets and neurons share many similarities including comparable secretory granule types with homologous calcium-dependent secretory mechanisms as well as internalization, sequestration and secretion of many neurotransmitters. Thus, platelets present ... -
A tutorial on dealing with time‐varying eligibility for treatment: Comparing the risk of major bleeding with direct‐acting oral anticoagulants vs warfarin
(Wiley, 2020-08-18)In this tutorial, we focus on the problem of how to define and estimate treatment effects when some patients develop a contraindication and are thus ineligible to receive a treatment of interest during follow-up. We first describe the concept of ... -
Tyrosine-based rivastigmine-loaded organogels in the treatmant of Alzheimer's disease
(2010-08)Organogels can be prepared by immobilizing an organic phase into a threedimensional network coming from the self-assembly of a low molecular weight gelator molecule. In this work, an injectable subcutaneous organogel system based on safflower oil and ... -
Understanding and diagnosing the potential for bias when using machine learning methods with doubly robust causal estimators
(SAGE, 2018-05-02)Data-adaptive methods have been proposed to estimate nuisance parameters when using doubly robust semiparametric methods for estimating marginal causal effects. However, in the presence of near practical positivity violations, these methods can produce ... -
Unified scaling of the structure and loading of nanoparticles formed via diffusion-limited coalescence
(American Chemical Society, 2018-04-30)The present study establishes the scaling laws describing the structure of spherical nanoparticles formed by diffusion-limited coalescence. We produced drug-loaded nanoparticles from a poly(ethylene glycol)-poly(d,l-lactic acid) diblock polymer (PEG-b-PLA) ... -
Universal cures for idiosyncratic illnesses: a genealogy of therapeutic reasoning in the mental health field
(SAGE Publications, 2014-08)Over the past decades, there has been a significant increase in prescriptions of psychotropic drugs for mental disorders. So far, most of the explanations of the phenomenon have focused on the process of medicalization, but little attention has been ... -
Unraveling the correlations between conformation, lubrication, and chemical stability of bottlebrush polymers at interfaces
(American Chemical Society, 2017-09-29)In the present study, we monitored the conformation and chemical stability of a hydrophilic bottlebrush (BB) polymer in pure water and buffered saline solutions. We correlated these parameters to lubricating and wear protecting properties. Using the ... -
Wear protection without surface modification using a synergistic mixture of molecular brushes and linear polymers
(American Chemical Society, 2017-01-10)We describe the design of lubricating and wear protecting fluids based on mixtures of bottlebrushes (BB) and linear polymers solutions. To illustrate this concept we used hyaluronic acid (HA) - a naturally occurring linear polyelectrolyte, and a water ...
