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dc.contributor.authorHanauer, Nicolas
dc.contributor.authorLatreille, Pierre-Luc
dc.contributor.authorAlsharif, Shaker
dc.contributor.authorBanquy, Xavier
dc.date.accessioned2015-12-01T17:27:11Z
dc.date.availableMONTHS_WITHHELD:12fr
dc.date.available2015-12-01T17:27:11Z
dc.date.issued2015-07-01
dc.identifier.citationHanauer, N., Latreille, P.L., Alsharif, S., Banquy, X. (2015). 2D, 3D and 4D Active Compound Delivery in Tissue Engineering and Regenerative Medicine. Current pharmaceutical design, 21(12), 1506-1516.fr
dc.identifier.urihttp://hdl.handle.net/1866/12672
dc.subjectNiche engineeringfr
dc.subjectControlled releasefr
dc.subjectScaffoldingfr
dc.subjectHydrogelfr
dc.subjectFiberfr
dc.title2D, 3D and 4D active compound delivery in tissue engineering and regenerative medicinefr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté de pharmaciefr
UdeM.statutÉtudiant(e) aux cycles supérieurs / Graduate Studentfr
dc.identifier.doi10.2174/1381612821666150115153417
dcterms.abstractRecent advances in tissue engineering and regenerative medicine have shown that controlling cells microenvironment during growth is a key element to the development of successful therapeutic system. To achieve such control, researchers have first proposed the use of polymeric scaffolds that were able to support cellular growth and, to a certain extent, favor cell organization and tissue structure. With nowadays availability of a large pool of stem cell lines, such approach has appeared to be rather limited since it does not offer the fine control of the cell micro-environment in space and time (4D). Therefore, researchers are currently focusing their efforts on developing strategies that include active compound delivery systems in order to add a fourth dimension to the design of 3D scaffolds. This review will focus on recent concepts and applications of 2D and 3D techniques that have been used to control the load and release of active compounds used to promote cell differentiation and proliferation in or out of a scaffold. We will first present recent advances in the design of 2D polymeric scaffolds and the different techniques that have been used to deposit molecular cues and cells in a controlled fashion. We will continue presenting the recent advances made in the design of 3D scaffolds based on hydrogels as well as polymeric fibers and we will finish by presenting some of the research avenues that are still to be explored.fr
dcterms.bibliographicCitationCurrent Pharmaceutical Design ; vol. 21, no 12
dcterms.isPartOfurn:ISSN:1873-4286
dcterms.isPartOfurn:ISSN:1381-6128
dcterms.languageengfr
UdeM.VersionRioxxVersion acceptée / Accepted Manuscript


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