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Bile acid-based drug delivery systems for enhanced doxorubicin encapsulation: Comparing hydrophobic and ionic interactions in drug loading and release
(American Chemical Society, 2018-01-29)
Doxorubicin (Dox) is a drug of choice in the design of drug delivery systems directed towards breast cancers, but is often limited by loading and control over its release from polymer micelles. Bile acid-based block ...
Non-covalent formulation of active principles with dendrimers: current state-of-the-art and prospects for further development
(Elsevier, 2017-09-06)
During the last three decades, dendrimers, nano-sized highly-branched fractal-like symmetrical macromolecules, have been intensively studied as promising candidates for application as drug-delivery carriers. Among other ...
Brain-derived neurotrophic factor mitigates the association between platelet dysfunction and cognitive impairment
(Frontiers media, 2021-09-07)
Background: Platelet hyperactivity is deleterious in coronary artery disease (CAD),
requiring lifelong antiplatelet therapy, and is associated with worse cognitive outcomes.
Upon activation, platelets release Brain-Derived ...
Differences in platelet-rich plasma composition influence bone healing
(Wiley, 2021)
Aim: Platelet-rich plasma (PRP) is an autologous blood-derived material that has been
used to enhance bone regeneration. Clinical studies, however, reported inconsistent
outcomes. This study aimed to assess the effect ...
Release kinetics from nano-inclusion-based and affinity-based hydrogels: A comparative study
(Elsevier, 2017-06-15)
In this study, we compare the release mechanisms from nanocomposite hydrogels. Liposomes made of different
compositions of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dihexadecanoyl-sn-glycero-3-phosphocholi ...
Quantification of peptides in human synovial fluid using liquid chromatography–tandem mass spectrometry
(Elsevier, 2018-04-06)
A method to explore the stability of two anti-inflammatory peptides in human synovial fluid (HSF) has been developed and validated using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The two peptides ...
Superlubricity of zwitterionic bottlebrush polymers in the presence of multivalent ions
(American Chemical Society, 2020-08-13)
In this study, we report lubrication properties of physisorbed zwitterionic bottlebrush polymers in the presence of
multivalent ions using the surface force apparatus. Unlike polyelectrolyte brushes, the lubrication ...
Platelet function in aging
(Frontiers Media, 2019-08-07)
Aging is associated with an increased incidence of cardiovascular disease and
thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus
formation, making them a key player in thrombotic disorders. ...
Unraveling the correlations between conformation, lubrication, and chemical stability of bottlebrush polymers at interfaces
(American Chemical Society, 2017-09-29)
In the present study, we monitored the conformation and chemical stability of a hydrophilic bottlebrush (BB) polymer in pure water and buffered saline solutions. We correlated these parameters to lubricating and wear ...
Consensus recommendations on flow cytometry for the assessment of inherited and acquired disorders of platelet number and function : communication from the ISTH SSC Subcommittee on Platelet Physiology
(Wiley, 2021-09-12)
Flow cytometry is increasingly used in the study of platelets in inherited and acquired disorders of platelet number and function. However, wide variation exists in specific reagents, methods, and equipment used, making ...