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In Vitro Ketamine CYP3A Mediated Metabolism Study using Mammalian Liver S9 Fractions, cDNA Expressed Enzymes and Liquid Chromatography Tandem Mass Spectrometry
(2014-12-01)
Ketamine is widely used in medicine in combination with several benzodiazepines including
midazolam. The objectives of this study were to develop a novel HPLC-MS/SRM method
capable of quantifying ketamine and norketamine ...
Evaluation of multiple reaction monitoring cubed for the analysis of tachykinin related peptides in rat spinal cord using a hybrid triple quadrupole–linear ion trap mass spectrometer
(2014-02)
Targeted peptide methods generally use HPLC-MS/MRM approaches. Although dependent on
the instrumental resolution, interferences may occur while performing analysis of complex
biological matrices. HPLC-MS/MRM3 is a ...