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Now showing items 11-15 of 15
Assessment of Tandem Mass Spectrometry and High Resolution Mass Spectrometry for the Analysis of Bupivacaine in Plasma
(2015-11-01)
Triple quadrupole mass spectrometers coupled with high performance liquid chromatography are
workhorses in quantitative bioanalyses. It provides substantial benefits including reproducibility,
sensitivity and selectivity ...
In Vitro Ketamine CYP3A Mediated Metabolism Study using Mammalian Liver S9 Fractions, cDNA Expressed Enzymes and Liquid Chromatography Tandem Mass Spectrometry
(2014-12-01)
Ketamine is widely used in medicine in combination with several benzodiazepines including
midazolam. The objectives of this study were to develop a novel HPLC-MS/SRM method
capable of quantifying ketamine and norketamine ...
Evaluation of multiple reaction monitoring cubed for the analysis of tachykinin related peptides in rat spinal cord using a hybrid triple quadrupole–linear ion trap mass spectrometer
(2014-02)
Targeted peptide methods generally use HPLC-MS/MRM approaches. Although dependent on
the instrumental resolution, interferences may occur while performing analysis of complex
biological matrices. HPLC-MS/MRM3 is a ...
Impact of Actinobacillus pleuropneumoniae biofilm mode of growth on the lipid A structures and stimulation of immune cells
(2016-05-25)
Actinobacillus pleuropneumoniae (APP), the etiologic agent of porcine pleuropneumonia, forms biofilms on biotic and abiotic surfaces. APP biofilms confers resistance to antibiotics. To our knowledge, no studies have examined ...
Resistance to colistin : what is the fate for this antibiotic in pig production?
(2016-08)
Colistin, a cationic polypeptide antibiotic, has reappeared in human medicine as a last-line treatment option for multidrug-resistant Gram-negative bacteria (MDR-GNB). Colistin is widely used in veterinary medicine for the ...