Browsing Faculté de médecine vétérinaire by Author "Pailleux, Floriane"
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Étude des tachykinines et de leurs dérivés peptidiques associés à la douleur neuropathique grâce à l’utilisation de modèles animaux et de la chromatographie en phase liquide couplée à la spectrométrie de masse
Pailleux, Floriane (2014-05-01)La gestion de la douleur neuropathique reste un challenge en médecine, malgré le nombre de traitements actuellement disponible. L’expérimentation animale a généré beaucoup d’informations concernant la douleur, mais ces connaissances demeurent insuffisantes ... -
Evaluation of multiple reaction monitoring cubed for the analysis of tachykinin related peptides in rat spinal cord using a hybrid triple quadrupole–linear ion trap mass spectrometer
Pailleux, Floriane; Beaudry, Francis (2014-02)Targeted peptide methods generally use HPLC-MS/MRM approaches. Although dependent on the instrumental resolution, interferences may occur while performing analysis of complex biological matrices. HPLC-MS/MRM3 is a technique, which provides a significantly ... -
In Vitro Ketamine CYP3A Mediated Metabolism Study using Mammalian Liver S9 Fractions, cDNA Expressed Enzymes and Liquid Chromatography Tandem Mass Spectrometry
Santamaria, Raphaël; Pailleux, Floriane; Beaudry, Francis (2014-12-01)Ketamine is widely used in medicine in combination with several benzodiazepines including midazolam. The objectives of this study were to develop a novel HPLC-MS/SRM method capable of quantifying ketamine and norketamine using an isotopic dilution ...