Parcourir Faculté de médecine par affiliation "Université de Montréal. Faculté de médecine. Département de microbiologie, infectiologie et immunologie"
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Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis
(Nature research, 2020-12-03)Iron homeostasis is an essential biological process that ensures the tissue distribution of iron for various cellular processes. As the major producer of hepcidin, the liver is central to the regulation of iron metabolism. The liver is also home to ... -
Addition of exogenous polypeptides on the mammalian reovirus outer capsid using reverse genetics
(Elsevier, 2012-02)Addition of exogenous peptide sequences on viral capsids is a powerful approach to study the process of viral infection or to retarget viruses toward defined cell types. Until recently, it was not possible to manipulate the genome of mammalian reovirus ... -
Algal Biofuels: Challenges and Opportunities
(Elsevier, 2013)Biodiesel production using microalgae is attractive in a number of respects. Here a number of pros and cons to using microalgae for biofuels production are reviewed. Algal cultivation can be carried out using non-arable land and non-potable water with ... -
Amino acid substitutions in σ1 and μ1 outer capsid proteins are selected during mammalian reovirus adaptation to Vero cells
(Elsevier, 2013-09)Establishment of viral persistence in cell culture has previously led to the selection of mammalian reovirus mutants, although very few of those have been characterized in details. In the present study, reovirus was adapted to Vero cells that, in ... -
Amino acids substitutions in σ1 and μ1 outer capsid proteins of a Vero cell-adapted mammalian orthoreovirus are required for optimal virus binding and disassembly
(Elsevier, 2015-01-01)In a recent study, the serotype 3 Dearing strain of mammalian orthoreovirus was adapted to Vero cells; cells that exhibit a limited ability to support the early steps of reovirus uncoating and are unable to produce interferon as an antiviral response ... -
Analysis of HIV-1 Vpr determinants responsible for cell growth arrest in Saccharomyces cerevisiae
(2004)BACKGROUND:The HIV-1 genome encodes a well-conserved accessory gene product, Vpr, that serves multiple functions in the retroviral life cycle, including the enhancement of viral replication in nondividing macrophages, the induction of G2 cell-cycle ... -
Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment
(2010)The Vpu accessory protein promotes HIV-1 release by counteracting Tetherin/BST-2, an interferon-regulated restriction factor, which retains virions at the cell-surface. Recent reports proposed beta-TrCP-dependent proteasomal and/or endo-lysosomal ... -
Association between disruption of CD4 receptor dimerization and increased human immunodeficiency virus type 1 entry
(2006)BACKGROUND:Human immunodeficiency virus (HIV) enters target cells by a membrane fusion process that involves a series of sequential interactions between its envelope glycoproteins, the CD4 receptor and CXCR4/CCR5 coreceptors. CD4 molecules are expressed ... -
Bisphosphoglycerate mutase deficiency protects against cerebral malaria and severe malaria-induced anemia
(Cell Press, 2020-09-22)The replication cycle and pathogenesis of the Plasmodium malarial parasite involves rapid expansion in red blood cells (RBCs), and variants of certain RBC-specific proteins protect against malaria in humans. In RBCs, bisphosphoglycerate mutase (BPGM) ... -
CD5 levels reveal distinct basal T-cell receptor signals in T cells from non-obese diabetic mice
(Wiley, 2021-02-03)Type 1 diabetes in non-obese diabetic (NOD) mice occurs when autoreactive T cells eliminate insulin producing pancreatic β cells. While extensively studied in T-cell receptor (TCR) transgenic mice, the contribution of alterations in thymic selection ... -
Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs
(Nature Research, 2021-05-21)The long-term survival of biomaterial implants is often hampered by surgery-induced inflammation that can lead to graft failure. Considering that most corneas receiving grafts are either pathological or inflamed before implantation, the risk of rejection ... -
Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits
(Rockefeller University Press, 2022-06-14)Interleukin 2 (IL-2) is a key homeostatic cytokine, with therapeutic applications in both immunogenic and tolerogenic immune modulation. Clinical use has been hampered by pleiotropic functionality and widespread receptor expression, with unexpected adverse ... -
Contribution of the C-terminal tri-lysine regions of human immunodeficiency virus type 1 integrase for efficient reverse transcription and viral DNA nuclear import
(2005)BACKGROUND:In addition to mediating the integration process, HIV-1 integrase (IN) has also been implicated in different steps during viral life cycle including reverse transcription and viral DNA nuclear import. Although the karyophilic property of ... -
The cumate gene-switch: a system for regulated expression in mammalian cells
(2006)BACKGROUND:A number of expression systems have been developed where transgene expression can be regulated. They all have specific characteristics making them more suitable for certain applications than for others. Since some applications require the ... -
The dichotomous pattern of IL-12R and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation
(Public Library of Science, 2014-02-21)IL-12 and IL-23 cytokines respectively drive Th1 and Th17 type responses. Yet, little is known regarding the biology of these receptors. As the IL-12 and IL-23 receptors share a common subunit, it has been assumed that these receptors are co-expressed. ... -
Effect of calcium-modulating cyclophilin ligand on human immunodeficiency virus type 1 particle release and cell surface expression of Tetherin
(2009)The HIV-1 accessory protein Vpu enhances virus particle release by counteracting a host factor that retains virions at the cell surface of infected cells. It was recently demonstrated that cellular protein BST2/CD317/Tetherin restricts HIV-1 release ... -
Evidence of genetic epistasis in autoimmune diabetes susceptibility revealed by mouse congenic sublines
(Springer, 2021-03-23)Susceptibility to autoimmune diabetes is a complex genetic trait. Linkage analyses exploiting the NOD mouse, which spontaneously develops autoimmune diabetes, have proved to be a useful tool for the characterization of some of these traits. In a linkage ... -
Exploring the Diversity of Physiology for Applications in Wastewater Treatment and Biofuels Production
(Algal Research, 2014-10)A recently established strain collection of freshwater microalgae native to Quebec was examined for physiological diversity. The 100 strains appeared very heterogeneous in terms of growth when they were cultured at 10±2 °C or 22±2 °C on the secondary ... -
Flt3L-Mediated expansion of plasmacytoid dendritic cells suppresses HIV infection in humanized mice
(Cell Press, 2019-11-26)Plasmacytoid dendritic cells (plasmacytoid DC, pDC) are major IFN-I producers and have been shown to be affected by HIV through ill-defined mechanisms. In this study, we directly assess the role of pDC in early infection, evaluating whether modulating ... -
Functional characterization of CaVα2δ mutations associated with sudden cardiac death
(Elsevier, 2015-01-30)L-type Ca(2+) channels play a critical role in cardiac rhythmicity. These ion channels are oligomeric complexes formed by the pore-forming CaVα1 with the auxiliary CaVβ and CaVα2δ subunits. CaVα2δ increases the peak current density and improves the ...